Results 31 to 40 of about 7,162,910 (287)
Smart CitiesIn post-war environments, property valuation encounters obstacles stemming from widespread destruction, population displacement, and complex legal frameworks. This study addresses post-war property valuation by integrating war-related considerations into
Mounir Azzam +3 more
doaj +1 more source
Vegaviana, a colonization village
Docomomo Journal, 2021 The Instituto Nacional de Colonización built a series of villages all over Spain to support farmers who were working on the newly established irrigated lands.
Inmaculada Bote Alonso +1 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Housing for the greatest number
Docomomo Journal, 2021 Addressing a broader vision, entitled “Housing for All”, this issue is dedicated to the welfare era, when governments across the world established ambitious housing programs to provide housing for the greatest number and improve the citizens’ living ...
Ana Tostões
doaj +3 more sources
Housing explorations. Unidad Vecinal Portales in Santiago
Docomomo Journal, 2021 This article explores the contribution of Unidad Vecinal Portales – built in Santiago de Chile by the studio Bresciani, Valdés, Castillo y Huidobro – to the debates on social housing in Chile between the 1940s and 1960s.
Umberto Bonomo
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Sunny flats will replace…A congested slum block
Docomomo Journal, 2021 The present text traces the post war slum clearance program in Sydney, Australia, that saw the construction of modern blocks of flats drawn from international examples of rehousing schemes. This State-funded urban renewal program continued from the late
Noni Boyd
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source