Results 111 to 120 of about 2,079,695 (308)

T817MA protects against inflammation and pyroptosis in response to brain ischemia via activating Sirt1 signaling

Scientific Reports
Ischemic stroke remains a leading cause of death and disability worldwide, yet effective neuroprotective therapies are lacking. Neuroinflammation and pyroptosis, a lytic and inflammatory form of programmed cell death, exacerbate secondary brain injury ...
Tao Wang, Ya-Juan Pan, Mei-Mei Zhang, Xuan Wang, Wei Li, Jian-Meng Lv   +5 more
doaj   +1 more source

Cardiac fibroblast-derived mitochondria-enriched sEVs regulate tissue inflammation and ventricular remodeling post-myocardial infarction through NLRP3 pathway

Pharmacological Research
Resident cardiac fibroblasts (CFs) play crucial roles in sensing injury signals and regulating inflammatory responses post-myocardial infarction (MI). Damaged mitochondria can be transferred extracellularly via various mechanisms, including extracellular
Yuanyuan Zhao, Ya Hu, Yifei Wang, Hao Qian, Chenxu Zhu, Hongjian Dong, Chunshu Hao, Yao Zhang, Zhenjun Ji, Xinxin Li, Yue Chen, Rongfeng Xu, Jie Jiang, Hailong Cao, Genshan Ma, Lijuan Chen   +15 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Remimazolam attenuates traumatic brain injury-induced acute lung injury by suppressing pulmonary epithelial pyroptosis

Journal of Neuroinflammation
Background and objectives TBI-induced acute lung injury (TBI-ALI), with an incidence rate of 22-25%, represents a critical determinant of secondary mortality. Remimazolam is a novel sedative that has shown potential for anti-inflammatory effects. However,
Chang Sun, Yi Zhang, Jiahan Wang, Bailun Wang, Angran Gu, Yuelan Wang, Changping Gu   +6 more
doaj   +1 more source

Arginine deprivation induces prolonged autophagy activation and ROS-dependent cell death in glioblastoma multiforme

CNS Oncology
Background Arginine deprivation was shown to be selectively cytotoxic to GBM cells with cell death being caspase-independent, non-apoptotic. In this study, we assess the impact of prolonged arginine deprivation on GBM cells, the potential activation of ...
Maya Abdelkhalek, Yasmin El-Jawhari, Maha Shaheen, Rawan Saad, Majd Sarieddine, Nour El-Husseini, Mirvat El-Sibai, Ralph J. Abi-Habib   +7 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Predicting Patient Satisfaction with Bimaxillary Surgery Outcomes: A Functional MRI Study of Neural Responses to Self-Images

Journal of the Korean Society of Radiology
Purpose This study aimed to utilize functional MRI (fMRI) to assess neural responses to preand post-bimaxillary surgery self-images to establish an objective predictor of patient satisfaction with the surgical results.
Jae Seung Kim, Changwoo Kang, Won-Jin Moon   +2 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Anle138b mitigates post-hypoxic cognitive impairment, α-Synuclein aggregation and UPR activation in Drosophila melanogaster

Acta Neuropathologica Communications
Cerebral ischemia increases the risk of post-stroke cognitive impairment (PSCI), but the underlying molecular mechanisms remain unclear. Emerging evidence suggests that hypoxia/ischemia-induced oxidative and endoplasmic reticulum (ER) stress may ...
Aaron T. Fehr, Jennifer Jung, Alma Kokott-Vuong, Sabri E. M. Sahnoun, Aya A. Ezzat, Michael Huber, Tonya M. Bliss, Aaron Voigt, Jörg B. Schulz, Pardes Habib   +9 more
doaj   +1 more source