Results 41 to 50 of about 241 (219)
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
EXARC Journal, 2014 A set of eleven articles resulting from the call for papers for the Sixth UK Experimental Archaeology Conference (held in York in January 2012) is now published in a special issue of the Journal of Archaeological and Anthropological Sciences.
Katy Whitaker
doaj
Journal of Palaeogeography, 2015 The synonymous use of the general term “landslide”, with a built-in reference to a sliding motion, for all varieties of mass-transport deposits (MTD), which include slides, slumps, debrites, topples, creeps, debris avalanches etc.
G. Shanmugam
doaj +1 more source
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
FEBS Open Bio, EarlyView.This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source
EXARC Journal, 2017 This book is a rewrite of Evis’ PhD thesis compiled between October 2010 and March 2014 at Bournemouth University (University of Exeter 2017). The study was an evaluation of the archaeological excavation methods and recording systems used in the United ...
Ceilidh Lerwick
doaj
Diagenetic, Nonevaporative Origin for Calcium Sulfate Salts at Gale Crater
Geochemistry, Geophysics, GeosystemsSulfate salts are deposited most commonly as evaporites on Earth; however, this is not their only origin. Pyrite oxidation during subsurface weathering is another common process on Earth that also produces a suite of sulfate salts—including the acidic ...
Hemani Kalucha +4 more
doaj +1 more source
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
The Mummification of Votive Birds: Past and Present
EXARC Journal, 2014 A mummy is defined as a ‘well-preserved dead body’ (Cockburn, Cockburn and Reyman 1998, 1), achieved by either natural or anthropogenic methods and refers to both human and animal subjects. Mummies achieved through both these methods are found in ancient
Stephanie D. Atherton +1 more
doaj
Clinical Validation of Plasma p‐217tau in Neurological Diseases
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi +13 more
wiley +1 more source