Results 51 to 60 of about 5,696,603 (238)

Real‐Time Ferroelectric Domain Wall Dynamics During Electric Poling and Depoling

Advanced Science, EarlyView.
Real‐time visualization of domain wall dynamics during alternating‐current poling, direct‐current poling, and electrical depoling in relaxor‐PT ferroelectric single crystals reveals distinct field‐dependent pathways and strong path dependence. Instant polarized light microscopy uncovers reversible domain wall nucleation, motion, and reconfiguration ...
Ziqi Wang, Zhengze Xu, Anastasia Timofeeva, Hossam Elnaggar, Sipan Liu, Yusen Pei, Reece Henry, Brendan O'Connor, Eunkyoung Shim, Franky So, Kara Peters, Xiaoning Jiang, Jun Liu   +12 more
wiley   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43

Advanced Science, EarlyView.
Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg, Anastasia Lopatina, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Bieber, Frank Schäfer‐Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas Stelzl, Martin Girard, Edward A. Lemke   +16 more
wiley   +1 more source

Lithium‐Ion Battery Safety Evaluation by Quantifying Lithium Plating Degree Based on Pressure Signals

Advanced Science, EarlyView.
Low N/P cells enable controllable lithium plating, allowing the lithium plating degree (DLi) to be quantified and linked to thermal safety. Pressure signals during calibration provide a non‐destructive route to diagnose DLi, while thermal response tests define safety levels and management strategies. The framework remains applicable in commercial 12 Ah
Haonan Liu, Jiangong Zhu, Wenyuan Weng, Bin Shen, Wenjun Fan, Yang Wang, Huapeng Lu, Wuliyasu He, Chunjing Lin, Xuezhe Wei, Haifeng Dai   +10 more
wiley   +1 more source

An assessment of the impact of environmental factors on the quality of post-mortem DNA profiling. [PDF]

, 2009
DNA profiling has ignited public interest and consequently their expectations for the capabilities of forensic criminal and science investigations. The prospect of characterising the genetic makeup of individuals or trace samples from a wide variety of ...
Gunawardane, Dalugama Mudiyanselage Don Dimuth Nilanga
core  

Various methods for the estimation of the post mortem interval from Calliphoridae: A review

Egyptian Journal of Forensic Sciences, 2015
Insects play a fundamental ecological role in the decomposition of organic matter. It is the natural tendency of sarcosaprophagous flies to find and colonize on a food source such as a cadaver as a natural means of survival.
Ruchi Sharma, Rakesh Kumar Garg, J.R. Gaur   +2 more
doaj   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Os reflexos, no direito sucessório, da inseminação artificial homóloga post mortem [PDF]

, 2014
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Jurídicas. Direito.A Medicina e a tecnologia avançam de tal forma que muitas vezes vão além do alcance do Direito.
Fabre, Ana Sofia de Souza
core  

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source