Results 1 to 10 of about 208,400 (200)

White matter hyperintensities and cerebral microbleeds in persistent post-traumatic headache attributed to mild traumatic brain injury: a magnetic resonance imaging study [PDF]

The Journal of Headache and Pain, 2023
Objective To examine whether white matter hyperintensities (WMHs) and cerebral microbleeds (CMBs) are more prevalent in people with persistent post-traumatic headache attributed to mild traumatic brain injury (TBI), compared with healthy controls ...
Håkan Ashina, Rune H. Christensen, Haidar Muhsen Al-Khazali, Afrim Iljazi, Daniel Tolnai, Anna K. Eigenbrodt, Henrik B. W. Larsson, Henrik W. Schytz, Ulrich Lindberg, Faisal Mohammad Amin   +9 more
doaj   +3 more sources

CGRP-induced migraine-like headache in persistent post-traumatic headache attributed to mild traumatic brain injury [PDF]

The Journal of Headache and Pain, 2022
Objective To ascertain whether intravenous infusion of calcitonin gene-related peptide (CGRP) can induce migraine-like headache in people with persistent post-traumatic headache attributed to mild traumatic brain injury (TBI) and no pre-existing migraine.
Håkan Ashina, Afrim Iljazi, Haidar M. Al-Khazali, Thien Phu Do, Anna K. Eigenbrodt, Eigil L. Larsen, Amalie M. Andersen, Kevin J. Hansen, Karoline B. Bräuner, Basit Ali Chaudhry, Casper E. Christensen, Faisal Mohammad Amin, Henrik W. Schytz   +12 more
doaj   +3 more sources

Introduction of a classification interview for post-traumatic headache after concussion [PDF]

The Journal of Headache and Pain
Background Mild traumatic brain injury (TBI) can cause temporary disruption to brain function, with up to half of those affected complaining of functional limitations up to 12 months after the initial injury.
Hannah S. Lyons, Matilde Sassani, Helen Brunger, Abigail Lake, Benjamin Jefferies, Mark Thaller, Andreas Yiangou, Victoria Homer, Shreshth Dharm-Datta, Henrietta Ellis, Manjit Matharu, Lisa J. Hill, James L. Mitchell, Alexandra J. Sinclair   +13 more
doaj   +3 more sources

Hypersensitivity to BKCa channel opening in persistent post-traumatic headache [PDF]

The Journal of Headache and Pain
Background Large conductance  calcium-activated potassium (BKCa) channels have been implicated in the neurobiological underpinnings of migraine. Considering the clinical similarities between migraine and persistent post-traumatic headache (PPTH), we ...
Haidar M. Al-Khazali, Rune H. Christensen, David W. Dodick, Basit Ali Chaudhry, Anna G. Melchior, Rami Burstein, Håkan Ashina   +6 more
doaj   +3 more sources

Inflammation, brain connectivity, and neuromodulation in post-traumatic headache [PDF]

Brain, Behavior, & Immunity - Health
Post-traumatic headache (PTH) is a debilitating condition that affects individuals with different levels of traumatic brain injury (TBI) severity.
Fernando da Silva Fiorin, Caroline Cunha do Espírito Santo, Joyce T. Da Silva, Man-Kyo Chung   +3 more
doaj   +3 more sources

Update on Non-Pharmacological Interventions for Treatment of Post-Traumatic Headache [PDF]

Brain Sciences, 2022
Post-traumatic headache (PTH) is the most common sequelae of traumatic brain injury (TBI). Its phenotypic variability, absence of formal evidence-based guidelines for treatment and underdiagnosis have made its management a challenge for clinicians.
Matthew J. Lee, Yi Zhou, Brian D. Greenwald   +2 more
doaj   +3 more sources

Effects of PDE-3 inhibition in persistent post-traumatic headache: evidence of cAMP-dependent signaling [PDF]

The Journal of Headache and Pain
Background Phosphodiesterase 3 (PDE-3) inhibition have been implicated in the neurobiologic underpinnings of migraine. Considering the clinical similarities between migraine and persistent post-traumatic headache (PPTH), we aimed to ascertain whether PDE-
Haidar M. Al-Khazali, Rune H. Christensen, Basit Ali Chaudhry, Anna G. Melchior, Messoud Ashina, Rami Burstein, Håkan Ashina   +6 more
doaj   +3 more sources

Characterization of persistent post-traumatic headache and management strategies in adolescents and young adults following mild traumatic brain injury [PDF]

Scientific Reports, 2022
Characteristics of persistent post-traumatic headache (PTH) in young individuals are poorly known leading to diagnostic problems and diverse management. We aimed to describe headache phenotypes and self-reported management strategies in young individuals
Simple Futarmal Kothari, Peter Preben Eggertsen, Oana Veronica Frederiksen, Mille Moeller Thastum, Susanne Wulff Svendsen, Astrid Tuborgh, Erhard Trillingsgaard Næss-Schmidt, Charlotte Ulrikka Rask, Andreas Schröder, Helge Kasch, Jørgen Feldbæk Nielsen   +10 more
doaj   +3 more sources

Identifying and predicting headache trajectories among those with acute post-traumatic headache. [PDF]

Headache
Post‐traumatic headache (PTH) is a common symptom following mild traumatic brain injury (mTBI). Currently, there is no identified way to accurately predict if, when, and at what pace a person will have PTH improvement. In our prior studies, we focused on
Mao L, Li J, Schwedt TJ, Wu T, Ross K, Dumkrieger G, Smith DC, Chong CD.   +7 more
europepmc   +2 more sources

Hypersensitivity to PACAP-38 in post-traumatic headache: a randomized clinical trial. [PDF]

Brain, 2023
Pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38), known for its role in migraine pathogenesis, has been identified as a novel drug target.
Al-Khazali HM, Christensen RH, Dodick DW, Chaudhry BA, Amin FM, Burstein R, Ashina H, Ashina H.   +7 more
europepmc   +2 more sources