Results 31 to 40 of about 64,371 (283)
Some personal and historical notes on the utility of deep-etch electron microscopy for making cell structure/function correlations [PDF]
, 2014 This brief essay talks up the advantages of metal replicas for electron microscopy and explains why they are still the best way to image frozen cells in the electron microscope. Then it explains our approach to freezing, namely the Van Harreveld trick of
Heuser, John E
core +2 more sources
A recipe for mediocrity and disaster, in five axioms
eLife, 2013 Biomedical research in the US will become unsustainable unless scientists and research institutions start to question certain assumptions they have long taken for granted.
Henry R Bourne
doaj +1 more source
First person – Sijie Tan and Wen Han Tong
Disease Models & Mechanisms, 2023 First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers.
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
PhD graduates at Czech Universities: the Account of their Study, Postdoc Options and Job Ambitions
Journal of Language and Cultural Education, 2019 The aim of the paper is to describe the PhD study and after graduation situation of graduates of Czech universities who completed their programme between 2010 - 2017.
Wiegerová Adriana
doaj +1 more source
How postdocs benefit from building a union
eLife, 2014 Members of UAW 5810—the union for postdoctoral researchers at the University of California—describe how their union has led to improved terms and conditions for postdocs.
Benjamin Cain +4 more
doaj +1 more source
The changing career paths of PhDs and postdocs trained at EMBL
eLife, 2023 Individuals with PhDs and postdoctoral experience in the life sciences can pursue a variety of career paths. Many PhD students and postdocs aspire to a permanent research position at a university or research institute, but competition for such positions ...
Junyan Lu +5 more
doaj +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A fair deal for PhD students and postdocs
eLife, 2013 The relentless expansion that threatens the sustainability of biomedical research in the US takes a heavy toll on young researchers.
Henry R Bourne
doaj +1 more source