Results 91 to 100 of about 192,015 (260)
IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd +9 morewiley +1 more sourcePoster presentation [PDF]
Surgical and Radiologic Anatomy, 2005 Shomali, T, Hamedi, Somayeh, Yaghoobfar, Akbar, Rezaian, Maryam, Majewski, Mariusz, Calka, Jaroslaw, Skobowiat, Cezary, Stanciulescu, Razvan, Pantu, Cosmin, Enyedi, Mihali, Tarta, Eugen, Filipoiu, Florin Mihail, Hedley, Gil, Benninger, Brion, D'Herde, Katharina, Kerckaert, Ingrid, Verstraete, Koenraad, Audenaert, Emmanuel, Gomes, Germano T, Van Hoof, Tom, Davari, Mohammad Hossein, Hassanzade, Mohamad Mahdi, Amini, Abdollah, Soleimani, Mansooreh, Maghoul, Shahin, Hosseini, Melina, Jafar-Kazemi, Koroush, Nasiri, Ebrahim, Can, Mehmet Ali, Bayram, Sule Biyik, Korkmaz, Ozgur, Bozkus, Ferdi Sefa, Kaygusuz, Mehmet Akif, Balioglu, Mehmet Bulent, Koebke, Jürgen, Komurcu, Mahmut, Ozboluk, Sener, Kurklu, Mustafa, Dinc, Gulten, Akkin, Salin Murat, Roghani, Mehrdad, Joghataie, Mohammad Taghi, Rasoolijazi, Homa, Denk, C Cem, Sargon, Mustafa F, Mocan, Burce Ozgen, Tatar, Emel Cadalli, Tatar, Ilkan, Celik, H Hamdi, Papadopoulos, Nikolaos, Anagnostopoulou, Sophia, Skandalakis, Panagiotis, Douvetzemis, Stergios, Piagkos, Giannoulis, Aikaterini, Vassiliki Kouki, Piagkou, Maria, Gholami, Mohammad Reza, Nezhad, Dariush Bijan, Zhaleh, Mohsen, Javadnia, Fatemeh, Gharravi, Anneh Mohammad, Saba, Mohamad, Abarghoeai, Parviz Raygan, Vaghefy, Raena Eftekhar, Eftekhar Vaghefy, Seyed Hasan, Vaghefi, Raena Eftekhar, Kohestani, Hamid Reza, Poraboli, Ali, Mahmodi, Abolghasem Amir, Eftekhar Vaghefi, Seyed Hasan, Abarghoeai, Parviz Rayegan, Abarghoeai, Roozbeh Rayegan, Kohestani, Hamid, Poya, Fateme, Moshkdanian, Ghazale, Eftekhar Vaghefi, Seyd Hasan, Zargarpoor, Rosa, Ghaem, Reza Montazer, Meibodi, Mohamad Ali Emami, Rayegan, Parviz, Ogut, Tahir, Akkin, Salih Murat, Ustundag, Sinan, Ayhan, Egemen, Nikzad, Hossein, Chegini, Hamidreza, Karacan, Kezban, Kosar, Mehmet Ilkay, Monabati, Ahmad, Mazaheri, Zohreh, Talaei, Tahereh, Namavar, Mohamad Reza, Berjis, Nezamedin, Naderian, Homayoun, Khanlarkhani, Neda, Abolidokht, A, Rajabalian, Saeed, Mousavi, A, Dabiri, Shahryar, Soroure-Azimzadeh, Behzad, Deilami, Masood, Latifpour, Mastafa, Nematollahi-Mahani, Seyed Noureddin, Sheibani, Vahid, Mohammadi, Abbas, Eftekharvaghefi, Seyed Hasan, Ebrahimzadeh, Alireza, Hassanzadeh Taheri, Mohammad Mehdi, Asgari, Alireza, Nourani, Mohammad Reza, Jamalpour, Zahra, Moaiery, Ardesheer, Elian, Amir Hossein, Dalili, Naser, Ahmadpoor, Mahmood Erfanian, Mahmoudian, Alireza, Kermanian, Fatemeh, Selthofer, Robert, Mrcela, Tomislav, Leksan, Igor, Prapa, Stamatia, Konstantinidi, Maria, Mitsaki, Charikleia, Francisco, Margarida, Hainoglou, Roxani, Sianou, Kyriaki, Mitsakis, Menelaos, Anastasiou, Aikaterini, Mitsakis, Ioannis, Haghparast, Elham, Khazei, Majid, Hami, Javad, Akbari, Asghar, Ghiasi, Fateme, Moodi, Hesam, Cimen, Mehmet, Erdil, F Hayat, Gumus, Cesur, Sabanciogullari, Vedat, Mazoochi, Tahereh, Ozbakir, Cemal, Cilingiroglu, Serpil, Ashwood, Neil, Fogg, Quentin, Loukas, Marios, Tubbs, R Shane, Radic, Radivoje, Nikolic, Vasilije, Jo-Osvatic, Ana, Krmek, Nikola, Krmek, Vlado, Veragara, Maria Elena, Cirillo, Angela, Freire, Diego, Sirilo, Angela, Rivara, Alvaro, Soria, Víctor, Almirón, Carina, Vergara, María Elena, Doassans, Inés, Poumayrac, Marie Catherine, Laza, Sebastián, Kachap, Mokhtar Jafarpoor, Javad, Hami, Ashrafi, Ali Reza, Ashrafi, Alireza, Amani, Zahra, Sheverdin, Vadim, Kim, Hyun-Ju, Sadeghimehr, Mohsen, Ashrafi, H R, Amani, A, Hosseini, Mohammad, Hosseinipanah, Seyed Mohammad, Abbasi, Hamed, Kim, Hyeon-Cheol, Park, Jong-Tae, Choi, Jong-Hoon, Kim, Hyun-Joo, Hong, Hee-Suk, Kim, Da-Hye, Celbis, Osman, Ulucam, Enis, Hur, Mi-Sun, Kim, Soo-Young, Kim, Soon-Heum, Choi, Hyun-Gon, Hwang, Eu-Na, Koh, Ki-Seok, Song, Wu-Chul, Kim, Yoo-Ri, Lee, Jeong-Yong, Lee, Ju-Young, Lee, Jae-Gi, Won, Sung-Yoon, Yang, Hun-Mu, Harma, Ahmet, Karakas, Hakki Muammer, Alicioglu, Banu, Gharravi, Annen Mohammad, Karagoz, Huseyin, Kapitonova, Marina Yurievna, Lovasova, Kvetuse, Nezhadi, Akram, Valderrama-Canales, Francisco, Ortug, Gursel, Nazhvani, Seifollah Dehghani, Nazhvani, Fatemeh Dehghani, Cavdar, Safiye, Cakmak, Yusuf Ozgur, Garzon, I, Ozkan, Derya, Pavlova, Velichka, Ogeturk, Murat, Selekler, Macit +214 moreopenaire +11 more sourcesHippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà +11 morewiley +1 more sourceDeciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall +14 morewiley +1 more sourceCCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets +12 morewiley +1 more sourceKDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan +16 morewiley +1 more source
