Results 181 to 190 of about 36,364 (254)

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Critical Vertebrobasilar Insufficiency From Left Intracranial Vertebral Artery Stenosis With Contralateral Hypoplasia Presenting as Recurring Vertigo: Urgent Stenting to Prevent the Progression of a Posterior Circulation Stroke. [PDF]

Cureus
Luan Z, Maud A, Yang X, Rodriguez GJ.
europepmc   +1 more source

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

Incidence and outcomes of posterior circulation stroke following traumatic vertebral artery injury: A 6-year single-center retrospective cohort study. [PDF]

J Craniovertebr Junction Spine
Sterne J, McLorinan G.
europepmc   +1 more source

Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), whereas dimethylaminohydrolase 1 (DDAH1) is primarily responsible for its metabolism. However, the roles of DDAH1 in cerebrovascular regulation are poorly understood. Furthermore, despite evidence that elevated ADMA levels are
Arun Flynn, Alexandra Riddell, Ashton Bernard, Jennifer Haggarty, Stefan Weidt, Jawza Alenazi, Erika Trabold, Delyth Graham, Laura B. Dowsett, James Leiper, Alyson A. Miller   +10 more
wiley   +1 more source

Posterior Circulation Stroke Due to Arterial Thoracic Outlet Syndrome: A Case Report and Literature Review. [PDF]

Ann Indian Acad Neurol
Iqbal R, Sriramakrishnan V, Saravanan S, Rajesh K, Ambrose FJ, Nandini R.   +5 more
europepmc   +1 more source

The role of macrophage migration inhibitory factor (MIF) in the pathogenesis and progression of cardiovascular disease

British Journal of Pharmacology, EarlyView.
Abstract Cardiovascular disease (CVD) remains the leading global cause of death, driven by complex mechanisms, in which chronic inflammation plays a central role. Inflammatory pathways contribute to all stages of CVD, from endothelial dysfunction and plaque formation to erosion, rupture and myocardial injury.
Shreya Mahabhashyam, James Harris, Jürgen Bernhagen, Antony Vinh, Katrina M. Mirabito Colafella   +4 more
wiley   +1 more source

Utilizing machine learning to facilitate the early diagnosis of posterior circulation stroke. [PDF]

BMC Neurol
Abujaber AA, Imam Y, Albalkhi I, Yaseen S, Nashwan AJ, Akhtar N.   +5 more
europepmc   +1 more source

Storying Multispecies‐Life‐and‐Death: Becoming‐Grief‐Able in Educational Spaces for Post‐Necrocene Futures

Children &Society, EarlyView.
ABSTRACT We situate this article from/with/in the Necrocene, a geological period marked by the systematic production of human and more‐than‐human death to an extent that ecological destruction, extinction, loss and harm have become a structural feature of modern life.
Charlotte Hankin, Hannah Hogarth
wiley   +1 more source