Results 71 to 80 of about 92,391 (275)

Mitigating measurement error in misspecified small area models

Canadian Journal of Statistics, EarlyView.
Abstract In the framework of Small area estimation, we consider an area‐level model where a subset of covariates is measured with error. The extent of the error is assumed to be constant throughout the areas, and it is expressed by a scalar parameter γ$$ \gamma $$, which multiplies the deterministic covariance matrix of the estimator of the true ...
Diego Battagliese, Serena Arima, Brunero Liseo, Alessio Pollice   +3 more
wiley   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Viral Dynamic Model‐Informed Dose Selection of Mosnodenvir Prophylaxis against DENV‐3 in a Controlled Human Infection Model

Clinical Pharmacology &Therapeutics, EarlyView.
Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Nele Goeyvaerts, Xavier Woot de Trixhe, Martine Neyens, Thomas N. Kakuda, Liesbeth Van Wesenbeeck, Annemie Buelens, Freya Rasschaert, Anna Durbin, Oliver Ackaert   +8 more
wiley   +1 more source

Adapting to Water Scarcity in Mediterranean Greenhouse Agriculture: Insights From Digital Irrigation and Regulated Water Governance in Southeastern Spain

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Climate‐driven water scarcity is compounding adaptation pressures on Mediterranean greenhouse farming, particularly for small and micro agricultural firms governed by regulated water‐governance systems. This paper analyses differentiated adaptation profiles in Almería (Spain) based on an analysis of farm structure, digital irrigation adoption,
Luis J. Belmonte‐Ureña, Francisco Camacho‐Ferre, Francisco José Castillo‐Díaz   +2 more
wiley   +1 more source

Improving maximum likelihood estimation using prior probabilities: A tutorial on maximum a posteriori estimation and an examination of the weibull distribution [PDF]

Tutorials in Quantitative Methods for Psychology, 2013
This tutorial describes a parameter estimation technique that is little-known in social sciences, namely maximum a posteriori estimation. This technique can be used in conjunction with prior knowledge to improve maximumlikelihood estimation of the best ...
Denis Cousineau, Sebastien Helie
doaj  

Anatomy of a SPAN Particle: A Four‐Level Structural Framework for Lithium–Sulfur Batteries

EcoEnergy, EarlyView.
Sulfurized polyacrylonitrile (SPAN) is a key cathode material for batteries. Borrowing the four‐level classification of protein structure, this perspective demonstrates SPAN's structural complexity into well‐defined levels, giving researchers clear research boundaries and targets at each level for improving battery performance.
Jinkwan Jung, Hyunseok Moon, Matthew Miyagishima, Jasper Zhang, Ying Shirley Meng, Shen Wang   +5 more
wiley   +1 more source

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

The prevalence of Streptococcus equi subsp. equi carriers in the Netherlands

Equine Veterinary Journal, EarlyView.
Abstract Background Streptococcus equi subspecies equi (S. equi) carriers are thought to be important drivers for strangles outbreaks. Limited data are available on the prevalence of carriers in European horse husbandry settings. Objectives To estimate the prevalence of S.
R. M. A. C. Houben, E. M. Broens, M. J. Broekhuizen‐Stins, M. M. Sloet van Oldruitenborgh‐Oosterbaan, C. van Maanen, J. A. P. Heesterbeek   +5 more
wiley   +1 more source

Unveiling Dental Students’ Baseline Self‐Regulated Learning Skills During an Authentic Diagnostic Reasoning Task

Journal of Dental Education, EarlyView.
ABSTRACT Purpose/Objectives This study aimed to cross‐culturally adapt and gather validity evidence for two instruments—the Self‐Regulated Learning Microanalytic Assessment (SRL‐MA) and the Assessment of Reasoning Tool—Reconstructed (ART‐R)—for assessing dental students' baseline self‐regulated learning (SRL) skills and diagnostic reasoning performance
Lorena Isbej, Dominique Waterval, Arnoldo Riquelme, Claudia Véliz, Ana Andaur, Paulina Freire, Anique B. H. de Bruin   +6 more
wiley   +1 more source

Impact of toothbrush type and periodontal phenotype on root coverage stability: A 6‐year observational follow‐up of a randomized clinical trial

Journal of Periodontology, EarlyView.
Abstract Background This 6‐year observational follow‐up of a randomized, parallel‐arm clinical trial evaluated the association between toothbrush type and periodontal phenotype on the long‐term stability of the gingival margin (GM) following coronally advanced flap (CAF) surgery.
Raffaele Acunzo, Enrico Limiroli, Silvia Ricoboni, Giorgia Saracino, Giulio Rasperini   +4 more
wiley   +1 more source