Results 71 to 80 of about 21,353 (254)
From mechanism to phenotype: What fits in a basket trial
Epilepsia, EarlyView.
Kette D. Valente
wiley +1 more source
European Journal of Haematology, Volume 116, Issue 2, Page 104-115, February 2026.ABSTRACT Background/Objectives Bruton tyrosine kinase inhibitors (BTKis) have revolutionized treatment for chronic lymphocytic leukemia (CLL), but cardiovascular (CV) toxicities pose significant challenges. Second‐generation BTKis offer improved target specificity, yet CV risks persist.
Stefano Oliva, Stefano Molica
wiley +1 more source
Sexual Medicine, 2020 Background: The Aveed Risk Evaluation and Mitigation Strategy program was instituted because of potential risk of pulmonary oil microembolism (POME) and/or anaphylaxis after intramuscular injection of Aveed (testosterone undecanoate), indicated for ...
Alexander W. Pastuszak, MD, PhD +2 more
doaj +1 more source
Effects of Modification of Pain Protocol on Incidence of Post Operative Nausea and Vomiting. [PDF]
, 2016 BackgroundA Perioperative Surgical Home (PSH) care model applies a standardized multidisciplinary approach to patient care using evidence-based medicine to modify and improve protocols.
Ahn, Kyle +7 more
core +2 more sources
FEBS Letters, Volume 600, Issue 2, Page 251-266, January 2026.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.This pharmacovigilance study systematically analyzed PD‐1 inhibitor–associated neurological adverse events using FAERS data from 2014 to 2024. Central nervous system toxicities, including encephalitis and brainstem encephalitis, were most prominent. Older age, female sex, specific cancer types, and combination therapies increased the risk, with most ...
Xiaofeng Hu +12 more
wiley +1 more source
The FDA, Preemption, and Public Safety: Antiregulatory Effects and Maddening Inconsistency [PDF]
, 2011 Most people think of preemption as a technical constitutional doctrine, but it is pivotally important to health and safety, while also opening the door to broad judicial discretion.
Gostin, Lawrence O.
core +1 more source
Impact of Elexacaftor‐Tezacaftor‐Ivacaftor on Quality of Life in Children With Cystic Fibrosis
Pediatric Pulmonology, Volume 61, Issue 1, January 2026.ABSTRACT Objectives CFTR modulators have revolutionized cystic fibrosis (CF) management by targeting the defective protein rather than its consequences. Their impact on quality of life (QoL) have been studied in numerous trials, but few data are available on QoL in patients receiving Elexacaftor‐Tezacaftor‐Ivacaftor (ETI), notably in children given its
Sara Kümmerli +6 more
wiley +1 more source
Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 1, January 2026.ABSTRACT Background The involvement and sponsorship of pharmaceutical and medical technology (MedTech) companies in deprescribing and medication optimization activities raise questions about conflicts of interest. We surveyed registrants and attendees of previous International Conferences on Deprescribing to explore views on the acceptability and ...
Katharina Tabea Jungo +3 more
wiley +1 more source
Postmarketing Studies: Benefits and Risks
Value in Health, 1999 To consider the benefits and risks of large postmarketing outcomes studies, as demonstrated by studies of the statin drugs.Literature review.The risks were that the statin studies had a strong coat-tail effect. Each new study was beneficial to all statins as well as the one studied.
Garfield, Frances B., Caro, J. Jaime
openaire +2 more sources