Results 1 to 10 of about 291,257 (288)

Evidence for Action on HIV Treatment and Care Systems in low and middle-income countries: background and introduction.

, 2012
Despite the unprecedented scale-up of treatment for HIV in low and middle-income countries over the past decade, 49% of adults and 77% of children in need of HIV treatment still do not have access to it.
Hakim, James, Ross, David A, South, Annabelle, Weller, Ian   +3 more
core   +1 more source

Everolimus plus exemestane in postmenopausal patients with HR(+) breast cancer: BOLERO-2 final progression-free survival analysis. [PDF]

, 2013
IntroductionEffective treatments for hormone-receptor-positive (HR(+)) breast cancer (BC) following relapse/progression on nonsteroidal aromatase inhibitor (NSAI) therapy are needed. Initial Breast Cancer Trials of OraL EveROlimus-2 (BOLERO-2) trial data
Arena, Francis P, Baselga, José, Burris, Howard A, Cahana, Ayelet, Campone, Mario, Erdkamp, Frans, Feng, Wentao, Gnant, Michael, Harb, Wael A, Hortobagyi, Gabriel N, Lebwohl, David, Melichar, Bohuslav, Noguchi, Shinzaburo, Petrakova, Katarina, Piccart, Martine, Pistilli, Barbara, Pritchard, Kathleen I, Rugo, Hope S, Taran, Tetiana, Yardley, Denise A   +19 more
core   +2 more sources

Incidence and time course of everolimus-related adverse events in postmenopausal women with hormone receptor-positive advanced breast cancer: insights from BOLERO-2. [PDF]

, 2014
BackgroundIn the BOLERO-2 trial, everolimus (EVE), an inhibitor of mammalian target of rapamycin, demonstrated significant clinical benefit with an acceptable safety profile when administered with exemestane (EXE) in postmenopausal women with hormone ...
Baselga, J, Bauly, H, Burris, HA, Chouinard, E, Csoszi, T, Eakle, J, El-Hashimy, M, Feng, W, Geberth, M, Gnant, M, Hortobagyi, G, Noguchi, S, Perez, A, Piccart, M, Pritchard, KI, Puttawibul, P, Rugo, HS, Srimuninnimit, V, Taran, T   +18 more
core   +1 more source

Comparison of epidemiological features, clinicopathological features, and treatments between premenopausal and postmenopausal female breast cancer patients in western China: a retrospective multicenter study of 15,389 female patients

Cancer Medicine, 2018
Premenopausal and postmenopausal breast cancers are considered different types. Thus, this study aimed to explore differences in risk factors, epidemiological features, clinicopathological features, and treatment modes of premenopausal breast cancer ...
Fan Feng, Yuxian Wei, Ke Zheng, Yujing Li, Lu Zhang, Tielin Wang, Yanli Zhang, Hongyuan Li, Guosheng Ren, Fan Li   +9 more
doaj   +1 more source

Low-grade endometrial stromal sarcoma in a postmenopausal woman with third-degree uterovaginal prolapse: A rare case with review of the literature

Journal of Mid-Life Health, 2018
Endometrial stromal sarcomas (ESSs) are rare malignant tumors of the uterus that arise from the endometrial stroma, the annual incidence of ESS being 1–2/million women.
Meenakshi Gothwal, Garima Yadav, Meenakshi Rao, Pratibha Singh, Aasma Nalwa   +4 more
doaj   +1 more source

Thyroxine-binding globulin: investigation of microheterogeneity [PDF]

, 1981
Preparations of T4-binding globulin (TBG) from human serum was performed using only two affinity chromatography steps. Purity of the protein was demonstrated by a single band in overloaded disc and sodium dodecyl sulfate electrophoresis, equimolar ...
Gärtner, Roland, Henze, R., Horn, K., Pickardt, C. R., Scriba, Peter Christian   +4 more
core   +1 more source

Bio-Calcium from Skipjack Tuna Frame Attenuates Bone Loss in Ovariectomy-Induced Osteoporosis Rats

Marine Drugs
Bio-calcium derived from fish frames may offer several advantages for osteoporosis prevention. This study aimed to evaluate the effects of bio-calcium derived from skipjack tuna frames on bone loss in ovariectomized rats.
Jirakrit Saetang, Acharaporn Issuriya, Watcharapol Suyapoh, Peerapon Sornying, Krisana Nilsuwan, Soottawat Benjakul   +5 more
doaj   +1 more source

Residential proximity to major roadways and prevalent hypertension among postmenopausal women: results from the Women's Health Initiative San Diego Cohort. [PDF]

, 2014
BackgroundLiving near major roadways has been linked with increased risk of cardiovascular events and worse prognosis. Residential proximity to major roadways may also be associated with increased risk of hypertension, but few studies have evaluated this
Adams, Marc A, Allison, Matthew A, Eaton, Charles B, Eliot, Melissa N, Kerr, Jacqueline, Kirwa, Kipruto, Morgan, Cindy G, Norman, Gregory J, Wang, Yi, Wellenius, Gregory A   +9 more
core   +1 more source

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. [PDF]

, 2012
BACKGROUND The intricate interactions between the immune, endocrine and central nervous systems shape the innate immune response of the brain. We have previously shown that estradiol suppresses expression of immune genes in the frontal cortex of ...
Carl Cotman, Erik Hrabovszky, Imre Kalló, István Likó, Miklós Sárvári, Nicole Berchtold, Norbert Solymosi, Sárvári, Miklós, Zsolt Liposits   +8 more
core   +2 more sources

Background risk of breast cancer and the association between physical activity and mammographic density [PDF]

, 2015
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if ...
A McTiernan, A McTiernan, A McTiernan, AH Eliassen, Arvid Sjölander, B Sternfeld, BE Ainsworth, CC Siozon, CG Woolcott, CM Friedenreich, CM Vachon, CM Vachon, DG Evans, F Bray, GA Greendale, Hatef Darabi, I Thune, J Stone, J Tyrer, JA Cauley, JA Shepherd, Jack Cuzick, JL Kelsey, JS Brand, Judith S Brand, JW Byng, K Walker, Kamila Czene, Katarina Bälter, KP Suijkerbuijk, KW Reeves, L Bernstein, L Bernstein, L Yaghjyan, LH Kushi, M Clemons, MC Pike, Mikael Eriksson, ML Irwin, ML Irwin, MP Warren, N Oestreicher, N Orsini, NF Boyd, NF Boyd, Per Hall, PM Janiszewski, R Highnam, RZ Stolzenberg-Solomon, SA Qureshi, SE Bonn, SS Maruti, SS Tworoger, SS Tworoger, Stephanie E Bonn, Thang Trinh, TM Peters, VA McCormack, WC Miller, Y Bremnes, Y Wu   +60 more
core   +2 more sources