Results 131 to 140 of about 89,178 (311)

Low‐dose lithium supplementation promotes musculoskeletal and metabolic health in ovariectomized female mice

The Journal of Physiology, EarlyView.
Abstract figure legend Low‐dose lithium supplementation in ovariectomized mice enhances skeletal muscle contractility (isometric force and fatigue resistance), SERCA function and promotes favourable transcriptional reprogramming, while increasing bone density and modestly improving insulin sensitivity.
Bianca M. Marcella, Jessica L. Braun, Amélie A.T. Marais, Briana L. Hockey, Mia S. Geromella, Ryan W. Baranowski, Rene Vandenboom, Rebecca E.K. MacPherson, Val A. Fajardo   +8 more
wiley   +1 more source

Postmenopausal Osteoporosis: From Mechanisms to Modern Therapies

Quality in Sport
Background. Osteoporosis is the most common metabolic bone disease and represents a serious public health problem, particularly among postmenopausal women. It is characterized by reduced bone mineral density and bone microarchitecture disorders, leading
Jakub Lambach, Kacper Kutnik, Weronika Woźnica, Julia Matuszewska, Michał Białogłowski, Alicja Maziarczyk, Anna Gęborys, Katarzyna Mazurek, Maja Wojcieszak, Dominika Miazga   +9 more
doaj   +1 more source

Presenilin L166P Mutation, a Model of Familial Alzheimer's Disease, Leads to Early Onset Bone Loss

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Female‐specific bone loss in Alzheimer's disease mouse models: There is a significant alteration of bone phenotype during Alzheimer's disease. Using integrated imaging and biological assays, we observed changes in the bone microarchitecture, composition, and function in PSEN K1 and PSEN1/hAPP Tg+ mice, predominantly in the females. ABSTRACT Accelerated
Vidyani Suryadevara, Connor J. Krehbial, Anuradha K. Valiya, Melinda Vang, Julian Balanta‐Melo, Pierre P. Eleniste, Sumana Posritong, Jung Min Hong, Katie Chester, Gabriel M. Pagnotti, Teresita Bellido, Monte S. Willis, Angela Bruzzaniti   +12 more
wiley   +1 more source

General practice [PDF]

, 2004
The remarkable rate of development of medical knowledge and pharmacology affects all medical specialties and in particular general practice, since the latter embraces various aspects of different medical fields. Certain areas of medical practice, such as
Abela, Jurgen C.
core  

Vildagliptin and Omarigliptin Differentially Bind to DPP‐4 Homodimers and Modulate Osteoclast‐Mediated Bone Resorption

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Vildagliptin and omarigliptin, dipeptidyl peptidase‐4 (DPP‐4) inhibitors, have differential effects on bone cells. Although vildagliptin improved the bone microstructure of high‐fat diet‐fed rats, it was unable to downregulate osteoclastogenesis or the expression of key osteoclast transcripts.
Ratchaneevan Aeimlapa, Jiraporn Panmanee, Jarinthorn Teerapornpuntakit, Kannikar Wongdee, Jirawan Thongbunchoo, Nattapon Panupinthu, Saovaros Svasti, Nattayaporn Apaijai, Piangkwan Sa‐nguanmoo, Siriporn Chattipakorn, Nipon Chattipakorn, Narattaphol Charoenphandhu   +11 more
wiley   +1 more source

Blood‐Based Lead Biomarkers and Sarcopenia Indicators in Older Adults

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Chronic exposure to low levels of lead (Pb) remains a widespread public health issue, especially among older adults. While its neurotoxic and cardiovascular effects are well recognized, its potential role in accelerating age‐related musculoskeletal decline is less understood.
Aida Koni, Alvaro Santos‐Cuerva, Mercedes Sotos‐Prieto, Rosario Ortolá, Pablo Olmedo, Javier García‐Pérez, Rebeca Ramis, Adrián Carballo‐Casla, Fernando Gil, Javier González‐Palacios, Roberto Pastor‐Barriuso, Ana Navas‐Acién, Elena Plans‐Beriso, Pablo Fernández‐Navarro, Fernando Rodríguez‐Artalejo, Esther García‐Esquinas   +15 more
wiley   +1 more source

Recommendations for raloxifene use in daily clinical practice in the Swiss setting [PDF]

, 2018
Background/aim: Raloxifene is the first selective estrogen receptor modulator that has been approved for the treatment and prevention of osteoporosis in postmenopausal women in Europe and in the US. Although raloxifene reduces the risk of invasive breast
Birkhäuser, M., Buchard, P., De Geyter, C., Imthurn, B., Lamy, O., Lippuner, Kurt, Litschgi, M., Luzuy, F., Schiessl, K., Stute, P.   +9 more
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Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

Prevalence and Risk Factors of Osteoporosis among Postmenopausal Women Visiting a District Hospital of Nepal: An Observational Study

Journal of Nepal Medical Association
Introduction: Osteoporosis and low bone mass affect millions of people worldwide, leading to severe consequences ranging from disability to mortality.
Dipendra Pandey, Samina Basnet, Smeena Pradhananga, Sarita Shrestha, Badri Rijal, Aman Neupane, Utsav Timilsina, Amit Upreti, Apil Upreti, Rabindra Baskota, Pawan Kumar Hamal   +10 more
doaj   +1 more source

The Role of Calcium in Osteoporosis [PDF]

Calcium requirements may vary throughout the lifespan. During the growth years and up to age 25 to 30, it is important to maximize dietary intake of calcium to maintain positive calcium balance and achieve peak bone mass, thereby possibly decreasing the ...
Arnaud, C. D., Sanchez, S. D.
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