Results 41 to 50 of about 191,162 (262)

Overview on postmenopausal osteoporosis and periodontitis: The therapeutic potential of phytoestrogens against alveolar bone loss

Frontiers in Pharmacology, 2023
Osteoporosis and periodontitis are two major chronic diseases of postmenopausal women. The association between these two diseases are evident through systemic bone loss and alveolar bone loss.
Putri Ayu Jayusman, Nurrul Shaqinah Nasruddin, Badiah Baharin, Nurul ‘Izzah Ibrahim, Haryati Ahmad Hairi, Ahmad Nazrun Shuid   +5 more
doaj   +1 more source

Similarity‐Enhanced Representation Learning of Non‐Canonical Amino Acids for Therapeutic Peptide Modeling

Advanced Science, EarlyView.
Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu, Lesong Wei, Jianmin Wang, Yuanpeng Xiong, Ruochi Zhang, Yu Wang, Chao Zha, Qiangcheng Zeng, Xin Gao   +8 more
wiley   +1 more source

When, where and how osteoporosis-associated fractures occur: An analysis from the global longitudinal study of osteoporosis in women (GLOW) [PDF]

, 2013
Objective: To examine when, where and how fractures occur in postmenopausal women. Methods: We analyzed data from the Global Longitudinal Study of Osteoporosis in Women (GLOW), including women aged ≥55 years from the United States of America, Canada ...
Anderson, Frederick A, Adachi, JD, Stephen H Gehlbach, Universitat Autònoma de Barcelona. Departament de Medicina, Adachi, Jonathan D., Chapurlat, Roland D., Frederick H Hooven, Díez Pérez, Adolfo, Nelson B Watts, Adachi, Jonathan D, Nieves, JW, Netelenbos, J.C., Lyn March, Boonen, S, Saag, Kenneth G., Compston, Juliet E., Roux, Christian, Pfeilschifter, Johannes, Rossini, Maurizio, Boonen, Steven, Pfeilschifter J, Ethel S Siris, Boonen S, Siris, E.S., Anderson, F.A., LaCroix, Andrea Z., Siris, Ethel S., Adami, Silvano, Adami, S., Watts NB, Jeri W Nieves, Lacroix, A.Z., Watts, NB, Gehlbach SH, Roux, C., Maurizio Rossini, Compston, JE, Gehlbach, S.H., Costa AG, Pfeilschifter, J., Rossini, M., Christian Roux, Boonen, S., Greenspan SL, Susan L Greenspan, Watts, N.B., Compston JE, Costa, Aline G. [UNIFESP], Greenspan, Susan L., Gehlbach, SH, March, L., Adami, S, Saag KG, Roux, C, Adachi JD, Saag, KG, Anderson, Frederick A., Greenspan, SL, Compston, Juliet E, Anderson FA Jr, Saag, Kenneth G, Hooven, Frederick H., Netelenbos JC, Cooper, C., March, Lyn, Díez Pérez A, Nieves, Jeri W., Cooper, C, Adachi, J.D., March, L, Nieves, Jeri W, Hooven, F.H., Andrea Z LaCroix, Silverman S, LaCroix, Andrea Z, Kenneth G Saag, Watts, Nelson B, Adolfo Díez-Pérez, Chapurlat, RD, Saag, K.G., Aline G Costa, Silverman, Stuart, Rossini, M, Juliet E Compston, Compston, J.E., Diez-Perez, A., Diez-Perez, Adolfo, Wyman, Allison, Stuart Silverman, Chapurlat, Roland D, Anderson Jr, Frederick A., Nieves JW, Silverman, S., Netelenbos, J. Coen, Jonathan D Adachi, Roux C, Cyrus Cooper, Gehlbach, Stephen H., Siris, Ethel S, Netelenbos, J Coen, Roland D Chapurlat, Siris, ES, Frederick A Anderson, March L, Pfeilschifter, J, Costa, A.G., Hooven, FH, Allison Wyman, LaCroix, AZ, Gehlbach, Stephen H, Lacroix AZ, Chapurlat, Roland, Wyman, A., Chapurlat, R.D., Greenspan, Susan L, Díez-Pérez, A, Silvano Adami, Anderson, FA, Cooper, Cyrus, Costa, Aline G, Chapurlat RD, Wyman, A, J Coen Netelenbos, Hooven, Frederick H, Hooven FH, Siris ES, Steven Boonen, Wyman A, Silverman, S, Costa, Aline G., Greenspan, S.L., Watts, Nelson B., Johannes Pfeilschifter, Netelenbos, JC, Nieves, J.W., Costa, AG, Cooper C, Nieves Jeri W., Adami Silvano, Anderson Frederick A., Siris Ethel S., Cooper Cyrus, Adachi Jonathan D., Netelenbos J. Coen, Gehlbach Stephen H., Watts Nelson B., Díez-Pérez Adolfo, Silverman Stuart, Greenspan Susan L., Compston Juliet E., LaCroix Andrea Z., Saag Kenneth G., Rossini Maurizio, Wyman Allison, Boonen Steven, March Lyn, Hooven Frederick H., Pfeilschifter Johannes, Roux Christian, Chapurlat Roland D., Costa Aline G.   +160 more
core   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Similarities in Acquired Factors Related to Postmenopausal Osteoporosis and Sarcopenia

Journal of Osteoporosis, 2011
Postmenopausal population is at increased risk of musculoskeletal impairments. Sarcopenia and osteoporosis are associated with significant morbidity and social and health-care costs.
Joonas Sirola, Heikki Kröger
doaj   +1 more source

The prevalence and treatment rate trends of osteoporosis in postmenopausal women.

PLoS ONE, 2023
BackgroundTo evaluate the prevalence and treatment of postmenopausal women with osteoporosis in recent years, analyze differences between the prevalence diagnosed by physicians and the prevalence detected by bone mineral density (BMD), and observe the ...
Xiaojuan Zhang, Zheng Wang, Di Zhang, Dandan Ye, Yaru Zhou, Jing Qin, Yingze Zhang   +6 more
doaj   +1 more source

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

Advanced Science, EarlyView.
Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi   +5 more
wiley   +1 more source

Hypercalciuria in Postmenopausal Osteoporosis [PDF]

, 2004
Women aged between 35 to 75, termed as postmenopausal at least for one year, not smoking and not drinking alcohol, not using any medicine related with menopause and osteoporosis made up our patient and control groups.
Hale Aral, Ayfer Kanberoğlu, Şule Tütün, Güvenç Güvenen   +3 more
core  

Whole-body vibration exercise in postmenopausal osteoporosis

, 2015
The report of the World Health Organization (WHO) of 2008 defines osteoporosis as a disease characterized by low bone mass and an increased risk of fracture.
Bartłomiej Niespodziński, Magdalena Weber-Rajek, Katarzyna Ciechanowska, Jan Mieszkowski   +3 more
core   +1 more source

Yoda1‐Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Advanced Science, EarlyView.
Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng, Ang Wang, Ren Zhang, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Jian Lu, Tong‐He Zhu, Jin‐Zhong Zhao, Shang‐Chun Guo, Shi‐Cong Tao   +16 more
wiley   +1 more source