Results 51 to 60 of about 191,162 (262)

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Incidence Rate of Concomitant Systemic Diseases in the Aging Population with Postmenopausal Osteoporosis

, 2016
Objective: To evaluate the concomitant systemic diseases with postmenopausal osteoporosis and to investigate the points to be considered in treatment approach of patients with osteoporosis.
Selçuk Sayılır, Sayilir, Selcuk
core   +1 more source

Are Bone Turnover Markers Related with Fracture Risk in Initial Diagnose Postmenopausal Osteoporosis? A Cross-Sectional Clinical Study [PDF]

, 2015
Objective: In this study, we investigated the relationships between 10 year fracture risk calculated with FRAX assessment tool and bone turnover markers (BTM) in women with diagnosed as postmenopausal osteoporosis for the first time.
Yalbuzdag, Seniz Akcay, Yalbuzdağ, Ş., Nuri Çetin, Çetin, N., İlker Şengül, Sarifakioglu, Banu, Akçay Yalbuzdağ, Şeniz, Sarıfakıo?lu, Ayşe Banu, Sengul, Ilker, Cetin, Nuri, Şengül, İ., Şeniz Akçay Yalbuzdağ, Banu Sarıfakıoğlu   +12 more
core   +1 more source

Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation

Advanced Science, EarlyView.
Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He   +10 more
wiley   +1 more source

Association of dyslipidaemia with osteoporosis in postmenopausal women

Journal of International Medical Research, 2021
Objective To assess the association of dyslipidaemia with osteoporosis in postmenopausal women. Methods Data from 160 postmenopausal women with newly diagnosed osteoporosis (osteoporosis group) and 156 healthy controls (control group) were ...
Lingnan Zhang, Qilong Liu, Xianshang Zeng, Wenshan Gao, Yanan Niu, Xiaoyong Ma, Huijun Xie, Xiaozhe Zhou, Weiguang Yu, Guixing Xu   +9 more
doaj   +1 more source

β2 -Microglobulin Levels in Patients with Postmenopausal Osteoporosis [PDF]

, 2003
The aim of this study was to evaluate the concentrations of b2 microglobulin in patients with postmenopausal osteoporosis and compare the results with the ones obtained from healthy postmenopausal women.
Pınar Ulaşan, Cengiz Öner, Funda Taşçıoğlu, Yıldıray Tabak   +3 more
core  

The Effect of Back Pain on Quality of Life, Sleep Quality and Depression in Patients with Postmenopausal Osteoporosis

, 2014
Objective: This study aimed to assess the effects of back pain on the quality of sleep, quality of life and depression in patients with postmenopausal osteoporosis.
Afitap İçağasioğlu, Hülya Uzkeser, Sema Haliloğlu, AFİTAB, İçağasioğlu, SEMA, Haliloğlu, UZKESER, Hülya   +5 more
core   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Relationship of Age, BMI, Serum Calcium and Estradiol with BMD in Postmenopausal Osteoporotic Females

Journal of Bahria University Medical and Dental College, 2011
Introduction: The current study was designed to investigate the relationship of age, body mass index (BMI), serum calcium and estradiol with bone mineral density (BMD) in postmenopausal females with and without osteoporosis.
Mukhtiar Baig, Mehreen Lateef, Abid Azhar   +2 more
doaj  

Sarcopenia and Sarcopenic Obesity in Postmenopausal Women: Limitations of BMI as a Predictor of Sarcopenic Obesity

AGING MEDICINE, EarlyView.
The prevalence of sarcopenia and sarcopenic obesity is large among community‐dwelling postmenopausal women, and lower body mass index is a significant predictor of both. The finding that low body mass index predicts both sarcopenia and sarcopenic obesity, highlights the limitation of body mass index as a measure of adiposity in the assessment of ...
Remya Rajan, Kripa Cherian, Thomas Paul, Hesarghatta Shyamasunder Asha, Arun Jose, Grace Rebekah, Nihal Thomas, Nitin Kapoor   +7 more
wiley   +1 more source