Results 71 to 80 of about 39,262 (226)

YTHDF3 Enhances Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoporosis by Promoting TBX19 Expression

Cell Proliferation, EarlyView.
In this study, OP‐BMSCs were successfully isolated from OVX osteoporotic rats. Mechanistic investigations revealed that the RNA‐binding protein YTHDF3 significantly upregulates Tbx19 expression by enhancing the stability of Tbx19 mRNA. Elevated Tbx19 levels, in turn, activate key osteogenic molecules, effectively promoting the differentiation of OP ...
Qianke Tao, Qiaonan Ye, Chengpeng Yang, Yuping Xie, Xuemei Long, Long Bai, Zhiyuan Zhang, Qianwei Li, Dan Tan, Jingang Xiao   +9 more
wiley   +1 more source

Deciphering epigenetic regulation in postmenopausal osteoporosis: Current and future perspectives

View
Postmenopausal osteoporosis is the most prevalent form of osteoporosis, affecting approximately 33% of postmenopausal women globally and representing a major cause of age‐related disability and mortality.
Xiumei Tang, Meiru Chen, Guixuan Xu, Yuan Li, Sen Guo, Yufeng Huang, Zhaoliang Hou, Xiaoling Hou, Zhijian Wei, Wenzhao Wang, Bing Ning   +10 more
doaj   +1 more source

Parathyroid carcinoma as an overlooked etiology of osteoporosis in postmenopausal women: a case report

Frontiers in Endocrinology
Parathyroid carcinoma (PC), an extremely rare endocrine malignancy, disrupts calciumphosphorus homeostasis and lead to musculoskeletal system disorders including osteoporosis, bone pain and pathological fractures.
Jing Su, Shiqiong Lei, Meiyuan Jin, Hongzhi Hu, Wenshan He   +4 more
doaj   +1 more source

Association between risk factors and bone mineral density and the development of a self-assessment tool for early osteoporosis screening in postmenopausal women with type 2 diabetes [PDF]

PeerJ
Background Both diabetes and osteoporosis have developed into major global public health problems due to the increasing aging population. It is crucial to screen populations at higher risk of developing osteoporosis for disease prevention and management ...
Xiaoyu Chen, Xiufen Jia, Junping Lan, Wenjun Wu, Xianwu Ni, Yuguo Wei, Xiangwu Zheng, Jinjin Liu   +7 more
doaj   +2 more sources

Cervical Small Cell Neuroendocrine Carcinoma Initially Detected on Cytology: Diagnostic Pitfalls and Clues

Cytopathology, EarlyView.
This case describes the initial detection of cervical small cell neuroendocrine carcinoma on conventional endometrial and cervicovaginal liquid‐based cytology. Given its rarity and high aggressiveness, early recognition and rapid, intensive treatment are crucial for improving patient outcomes.
Yesul Jeong
wiley   +1 more source

Weight-adjusted waist index as a new predictor of osteoporosis in postmenopausal patients with T2DM

Scientific Reports
This study aimed to investigate the predictive value of the weight-adjusted waist index (WWI) for osteoporosis in postmenopausal patients with type 2 diabetes mellitus (T2DM).
Guohui Du, Linna Zeng, Jingyuan Lan, Junru Liu, Xing Wang, Lina Sun, Dongmei Fan, Ning Wang, Lanyu Lu, Bowei Liu, Fuzai Yin   +10 more
doaj   +1 more source

Serum IL-17 and postmenopausal osteoporosis

مجلة كلية الطب, 2016
Background: Osteoporosis is a bone condition that makes bones thininer and more fragile because of reduced bone density and it puts people at risk of fractures, especially of the hip, spinal vertebrae and wrist. Objective: This study will highlighted the
Tharwa H. AL-Tai
doaj   +1 more source

Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib, Francisco Emilio Fierro, Maria Ortega Abad, Ricardo Correa   +3 more
wiley   +1 more source

Association Between Allometric Body Shape Indices and Osteoporosis in Postmenopausal Women: A Cross-Sectional Study from NHANES

International Journal of Women's Health
Songfeng Zhao,1,2 Xin Pan1,2 1Department of Endocrinology, The First People’s Hospital of Xiaoshan District, Hangzhou, Zhejiang, People’s Republic of China; 2Department of Endocrinology, Xiaoshan Affiliated Hospital of Wenzhou Medical University ...
Zhao S, Pan X
doaj  

PRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized mice

Experimental and Molecular Medicine, 2018
Osteoporosis: protein trigger for postmenopausal bone loss identified A protein that helps trigger bone loss in postmenopausal osteoporosis could be a potential therapeutic target.
Joo-Hee Choi, Ah-Ra Jang, Dong-il Kim, Min-Jung Park, Seul-Ki Lim, Myung-Sun Kim, Jong-Hwan Park   +6 more
doaj   +1 more source