Results 91 to 100 of about 158,147 (315)

The thyroid gland in postmenopausal women: physiology and diseases [PDF]

, 2017
The incidence of most thyroid diseases: hypothyroidism, nodular goitre, and cancer is highest among postmenopausal and elderly women. The diagnosis of thyroid dysfunction in this group of patients is difficult because the symptoms can be nonspecific or ...
Małgorzata Gietka-Czernel
core   +1 more source

Resolving CYP2D6 Structural Complexity with Long‐Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Cytochrome P450 2D6 (CYP2D6)‐mediated bioactivation of tamoxifen to endoxifen is a key determinant of therapeutic efficacy in estrogen receptor‐positive breast cancer. In Asian populations, the high prevalence of structurally complex CYP2D6 alleles complicates conventional genotyping, limiting accurate genotype–phenotype correlation.
Usa Boonyuen, Sirinyatorn Talukam, Beatriz Aira C. Jacob, Wayu Matphong, Kamonwan Chamchoy, Onrapak Reamtong, Nuntana Meesiripan, Junya Yamagishi, Matthew Phanchana, Chayanoot Rattadilok   +9 more
wiley   +1 more source

Importance of Osteoporosis in Family History of Postmenopausal Osteoporotic Women - Original Investigation [PDF]

, 2006
Aim: Osteoporosis (OP) appears as a result of reduction in bone mass and deformation of micro structure is widely found in postmenopausal period. Research into etiologic risk factor and by taking required precautions may assist to prevent negative ...
Derya Demirbağ Kabayel, Ferda Özdemir, Mevlüt Türe   +2 more
core  

Osteoporosis and polymorphisms of osteoprotegerin gene in postmenopausal women – a pilot study [PDF]

, 2016
Objectives: Osteoprotegerin (OPG) has an important role in bone remodeling, and it has been proposed that the OPG gene might be a candidate gene for osteoporosis predisposition.
Pasezada Kosovic, Selma Cvijetic, Tomislav Nemcic, Melita Uremovic, Jasminka Bobic, Simeon Grazio   +5 more
core   +1 more source

Food‐grade proteins, lipids, and fibers as potential tools to ameliorate cardiovascular disorders: A review

Food Biomacromolecules, EarlyView.
Abstract Cardiovascular diseases (CVDs) remain the leading cause of global mortality, necessitating effective preventive and adjunct therapeutic strategies beyond conventional pharmacological interventions. Although previous reviews have focused on individual nutrients or dietary patterns, this review provides a mechanism‐based, integrative perspective
Sridevi Shanmugam, Rukaiah Fatma Begum, Nirenjen Shanmugasundaram, Bhupendra Gopalbhai Prajapati, Suresh Ankul Singh, Pavithra Nagenthran, Sudarshan Singh, Kesarla Rajesh   +7 more
wiley   +1 more source

Association between Bone Mineral Density and Platelet Indices in Postmenopausal Women [PDF]

, 2016
Objective: It was shown that low bone mass is associated with increased cardiovascular mortality in early and late menopausal period. The aim of this study was to investigate the relationship between bone mineral density (BMD) and platelet indices (mean ...
Adem Yıldırım, Hacı Taner Bulut
core   +1 more source

Chemotherapy‐Induced Nausea and Vomiting in Early Breast Cancer Patients Receiving Adjuvant Chemotherapy With Fluorouracil, Epirubicin, Cyclophosphamide Followed by Docetaxel Versus an Anthracycline‐Free Regimen With Docetaxel, Cyclophosphamide—Results From a Randomized Clinical Trial

International Journal of Cancer, EarlyView.
Chemotherapy‐induced nausea and vomiting (CINV) remains a significant clinical problem despite modern antiemetics. In particular, antiemetic strategies for emerging cancer therapies lack detailed evaluation. This randomized trial analyzed hourly CINV data for patients with early breast cancer who received either docetaxel plus cyclophosphamide (TC) or ...
Manuel Hörner, Henning Schäffler, Lothar Häberle, Chloë Goossens, Kerstin Pfister, Elena Leinert, Kristina Veselinovic, Sara Y. Brucker, Uwe Köhler, Georg Heinrich, Andreas Schneeweiss, Matthias W. Beckmann, Peter A. Fasching, Wolfgang Janni, Brigitte Rack, Sabine Heublein, Philipp Ziegler   +16 more
wiley   +1 more source

Prevalence of Thyroid Dysfunction Among Postmenopausal Women in Baghdad Medical City [PDF]

Background: One of the most frequent endocrine abnormalities and changes in females, especially during the postmenopausal period, is thyroid dysfunction.
Hayder AL-MOMEN, Sajad Adel Abdul HUSSEIN, Harith Abdul Rahman IBRAHIM, Shaymaa Kadhim JASIM, Abdullah Ahmed MAHDI   +4 more
core   +1 more source

De‐Escalation of Neoadjuvant Treatment for HER2‐Positive Breast Cancer

International Journal of Cancer, EarlyView.
ABSTRACT With improved prognosis in early HER2‐positive breast cancer, safely de‐escalating treatment is increasingly investigated to minimize overtreatment. This article focuses on neoadjuvant de‐escalation strategies for HER2‐positive breast cancer.
Yiyin Ma, Dedian Chen, Sheng Huang
wiley   +1 more source

Intraocular pressure in postmenopausal Nigerian women with and without systemic hypertension

African Vision and Eye Health, 2011
Background: Mean intraocular pressure (IOP) in postmenopausal women has been reported higher than that in menstruating women. Also, intraocular pressure is said to be positively correlated with systemic blood pressure.
J. A. Ebeigbe, P. N. Ebeigbe, A. D. A Ighoroje   +2 more
doaj   +1 more source