Results 31 to 40 of about 132,813 (262)

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source

Postmortem for Intensified Missed Tuberculosis Case Finding in High Human Immunodeficiency Virus and Tuberculosis-burdened Settings in Sub-Saharan Africa among Adults’ Population: Systematic Review and Meta-analysis

International Journal of Mycobacteriology
Tuberculosis (TB) is the leading infectious cause of mortality in sub-Saharan Africa (SSA); the high prevalence of TB in this region is due to human immunodeficiency virus (HIV)-coinfection. Despite the advent of modalities to diagnose TB, undiagnosed TB-
Emmanuel M. Sindato, Abdallah Mlwati, Sylivia Sarah Swai, Violet Dismas Kajogoo   +3 more
doaj   +1 more source

Granulomatous Myocarditis as Rare Presentation of Mycobacterium tuberculosis: A Series of Four Autopsy Cases [PDF]

Journal of Clinical and Diagnostic Research
Tuberculosis (TB) is a communicable disease caused by the organism Mycobacterium tuberculosis. It has been a leading cause of mortality and a global public health emergency for the last 25 years.
Shalaka Anand Deshpande, Manisha Khare, Prashant V Kumavat, Sneha Janjal   +3 more
doaj   +1 more source

POSTMORTEM REFLEXES [PDF]

Journal of the American Medical Association, 1915
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openaire   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Human Metapneumovirus-associated Atypical Pneumonia and SARS

Emerging Infectious Diseases, 2004
Acute pneumonia developed in a previously healthy man during the outbreak of severe acute respiratory syndrome (SARS) in southern China in March 2003. Antibiotic treatment was ineffective, and he died 8 days after illness onset. Human metapneumovirus was
Paul K.S. Chan, Ka-Fai To, Alan Wu, Gary M.K. Tse, Kui-Fat Chan, Siu-Fai Lui, Joseph J.Y. Sung, John S. Tam, Brian Tomlinson   +8 more
doaj   +1 more source

New Perspectives for Postmortem Human Satellite Cells of Different Embryological Origin

Frontiers in Physiology, 2022
Human postmortem skeletal muscles are a unique source of satellite cells for skeletal muscle regenerative studies. Presomite and somite satellite cells obtained by postmortem muscles have been established as populations of human skeletal muscle precursor
Tiziana Pietrangelo, Tiziana Pietrangelo, Roberto Demontis, Carmen Santangelo, Carmen Santangelo, Niccolò Pini, Martina Bonelli, Enrica Rosato, Paola Roberti, Marcello Locatelli, Angela Tartaglia, Lorenzo Marramiero, Lorenzo Marramiero, Vittore Verratti, Danilo Bondi, Danilo Bondi, Stefania Fulle, Stefania Fulle, Ernesto D’Aloja, Cristian D’Ovidio   +19 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Post-Mortem Analysis of Heroin Biomarkers, Morphine and Codeine in Stomach Wall Tissue in Heroin-Related Deaths

Toxics, 2022
Toxicological analysis of some cases can be complicated by poor sample quality caused by decomposition. Although heroin-related deaths have been researched extensively, the interpretation of toxicology findings in these cases is challenging, especially ...
Ahmed I. Al-Asmari, Hassan Alharbi, Torki A. Zughaibi   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source