Results 41 to 50 of about 56,182 (257)

Focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with Alzheimer disease neuropathology

Acta Neuropathologica Communications, 2022
Quantification of in vivo amyloid and tau PET imaging relationships with postmortem measurements are critical for validating the sensitivity and specificity imaging biomarkers across clinical phenotypes with Alzheimer disease neuropathologic change (ADNC)
Adam Martersteck, Ivan Ayala, Daniel T. Ohm, Callen Spencer, Christina Coventry, Sandra Weintraub, Eileen H. Bigio, M. -Marsel Mesulam, Changiz Geula, Emily Rogalski   +9 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Postmortem liver hypostases in newborns: radiation and pathological characteristics [PDF]

Digital Diagnostics
BACKGROUND: During pathological and forensic autopsies, the bodies of the deceased are examined to identify nonspecific cadaveric changes. These changes include internal hypostases, which are characterized by the redistribution of blood in tissues and ...
Oksana V. Savva, Ulyana N. Tumanova, Vladimir G. Bychenko, Aleksandr I. Shchegolev   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Current Understanding and Future Research Direction for Estimating the Postmortem Interval: A Systematic Review

Diagnostics
Background: Accurate estimation of the postmortem interval (PMI) is critical in forensic death investigations. Traditional signs of death—algor mortis, livor mortis, and rigor mortis—are generally reliable only within the first two to three days after ...
Gabriela Strete, Andreea Sălcudean, Adina-Alexandra Cozma, Carmen-Corina Radu   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

From Fragile Lives to Forensic Truth: Multimodal Forensic Approaches to Pediatric Homicide and Suspect Death

Diagnostics
Background: Forensic investigation of child homicides presents unique challenges due to the vulnerability of children and the complexity of distinguishing between natural, accidental, and intentional manner of death.
Kallirroi Fragkou, Ioannis Ketsekioulafis, Athina Tousia, Maria Piagkou, Flora Bacopoulou, Panagiotis Ferentinos, Pierre-Antoine Peyron, Eric Baccino, Laurent Martrille, Stavroula Papadodima   +9 more
doaj   +1 more source

The Influence of Eyelid Position and Environmental Conditions on the Corneal Changes in Early Postmortem Interval: A Prospective, Multicentric OCT Study

Diagnostics, 2022
In the current study, using portable optical coherence tomography, we evaluated 46 corneas of 23 individuals in a multicenter setting during the first 17 h after death. Twenty-three eyes were kept open, and twenty three were kept closed. Furthermore, the
Matteo Nioi, Pietro Emanuele Napoli, Roberto Demontis, Alberto Chighine, Fabio De-Giorgio, Simone Grassi, Vincenzo Scorcia, Maurizio Fossarello, Ernesto d’Aloja   +8 more
doaj   +1 more source

Virtopsy: Postmortem Imaging of Laryngeal Foreign Bodies

Archives of Pathology & Laboratory Medicine, 2009
Abstract Context. —Death from corpora aliena in the larynx is a well-known entity in forensic pathology. The correct diagnosis of this cause of death is difficult without an autopsy, and misdiagnoses by external examination alone are common.
Oesterhelweg, Lars, Bolliger, Stephan, Thali, Michael J, Ross, Steffen   +3 more
openaire   +4 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source