Results 51 to 60 of about 56,182 (257)

How to report perinatal and paediatric postmortem CT

Insights into Imaging
Postmortem CT (PMCT) has become increasingly accepted alongside skeletal surveys as a critical part of investigation in childhood deaths, either as part of a suite of non-invasive investigations through parental choice, or comprehensive evaluation in a ...
Susan C. Shelmerdine, Owen J. Arthurs
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Deep Learning-Based Detection of Intracranial Hemorrhages in Postmortem Computed Tomography: Comparative Study of 15 Transfer-Learned Models

Applied Sciences
With the increasing use of postmortem imaging, deep learning (DL)-based automated analysis may assist in the detection of intracranial hemorrhages. However, limited postmortem data complicate model training.
Rentaro Matsumoto, Hidetoshi Matsuo, Marie Sugimoto, Takaaki Matsunaga, Mizuho Nishio, Atsushi K. Kono, Gentaro Yamasaki, Motonori Takahashi, Takeshi Kondo, Yasuhiro Ueno, Ryuichi Katada, Takamichi Murakami   +11 more
doaj   +1 more source

Impact of anthropometry training and feasibility of 3D imaging on anthropometry data quality among children under five years in a postmortem setting.

PLoS ONE, 2023
BackgroundThe Child Health and Mortality Prevention Surveillance Network (CHAMPS) identifies causes of under-5 mortality in high mortality countries.ObjectiveTo address challenges in postmortem nutritional assessment, we evaluated the impact of ...
Priya M Gupta, Kasthuri Sivalogan, Richard Oliech, Eugene Alexander, Jamie Klein, O Yaw Addo, Dickson Gethi, Victor Akelo, Dianna M Blau, Parminder S Suchdev   +9 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Autopsy Pathology’s Paradigm Shift: Artificial Intelligence and Emerging Technologies in the Era of Digitally Integrated Death Investigation

Diagnostics
Background: Autopsy pathology remains the reference standard for determining the cause of death, reconstructing disease and injury mechanisms, ensuring diagnostic quality, and supporting medical education and forensic investigations.
Ivan Dieb Miziara, Carmen Silvia Molleis Galego Miziara   +1 more
doaj   +1 more source

3D micro-CT imaging of the postmortem brain [PDF]

Journal of Neuroscience Methods, 2008
Magnetic resonance microscopy (microMRI) is becoming an important tool for non-destructive analysis of fixed brain tissue. However, unlike MRI, X-ray computed tomography (CT) scans show little native soft tissue contrast. In this paper, we explored the use of contrast enhanced (brains immersion stained in iodinated CT contrast media) micro-CT (microCT)
Alex, de Crespigny, Hani, Bou-Reslan, Merry C, Nishimura, Heidi, Phillips, Richard A D, Carano, Helen E, D'Arceuil   +5 more
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Impact of partial volume correction on the regional correspondence between in vivo [C-11]PiB PET and postmortem measures of Aβ load

NeuroImage: Clinical, 2018
The positron emission tomography (PET) radiotracer Pittsburgh Compound B ([C-11]PiB) demonstrates a high affinity for fibrillary amyloid-beta (Aβ) aggregates. However, [C-11]PiB's in vivo sensitivity and specificity is an ongoing area of investigation in
Davneet S. Minhas, Julie C. Price, Charles M. Laymon, Carl R. Becker, William E. Klunk, Dana L. Tudorascu, Eric E. Abrahamson, Ronald L. Hamilton, Julia K. Kofler, Chester A. Mathis, Oscar L. Lopez, Milos D. Ikonomovic   +11 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source