Results 231 to 240 of about 65,285 (343)

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

Advanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
wiley   +1 more source

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

Advanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu, Yuyu Wu, Yingjie Chen, Xiyi Chen, Xingjie Zan, Yanlong Liu, Wujun Geng   +6 more
wiley   +1 more source

Estimation of Postmortem Interval Using Various Markers in the Liver of Adult Albino Rats (Targeting the PTEN/FasL Signaling Pathway) [PDF]

Rabab Fawzy Hindawy, Eman Mohamed Faruk, Samia Manawy, Basma A. Ibrahim, Doaa Elsayed Abdelrazzak, Nahla M. Ibrahim   +5 more
openalex   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Postmortem interval estimation of human skeletonized remains through luminol chemiluminescence. [PDF]

Int J Legal Med
Ermida C, Rosa J, Cunha E, Ferreira MT.
europepmc   +1 more source

The immunohistochemical localization of alpha1-antichymotrypsin and fibronectin and its meaning for the determination of the vitality of human skin wounds [PDF]

, 1993
A. Nerlich, AB Nevelös, C Hernandez-Cueto, E Bdhm, E Bdhm, IG Fazekas, J Lindner, J Raekallio, J Raekallio, J Raekallio, J Raekallio, J Raekallio, J. Tübel, J. Wilske, JA Lorente, K Laiho, K Laiho, K Walcher, K Walcher, M Oehmichen, M Oehmichen, M Oehmichen, P Betz, P. Betz, R Jarecki, R. Penning, RW Berninger, S Berg, SM Hsu, V Schneider, W Bonte, W. Eisenmengen, Y Maeno   +32 more
core   +1 more source

Estimating the postmortem interval in forensic cases through the analysis of postmortem deterioration of human head hair

, 2004
Jamie Collier, Jamie Collier
openalex   +2 more sources

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Potential Role of mRNA in Estimating Postmortem Interval: A Systematic Review. [PDF]

Int J Mol Sci
Cianci V, Mondello C, Sapienza D, Guerrera MC, Cianci A, Cracò A, Omero F, Gioffrè V, Gualniera P, Asmundo A, Germanà A.   +10 more
europepmc   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source