Results 101 to 110 of about 437,688 (307)

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Postnatal development of the optic nerve in (C57BL x CBA)F1 hybrid mice:general changes in morphometric parameters [PDF]

, 1996
A morphometric analysis of the optic nerve in different age groups of (C57BL x CBA)F1 hybrid mice was carried out. Morphometric parameters examined were mean nerve cross-sectional area (csa), mean myelinated nerve fibre count, mean myelinated nerve fibre
Dangata, Y Y, Findlater, G S, Kaufman, M H   +2 more
core  

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Safe start at home : what parents of newborns need after early discharge from hospital - a focus group study [PDF]

, 2016
The length of postpartum hospital stay is decreasing internationally. Earlier hospital discharge of mothers and newborns decreases postnatal care or transfers it to the outpatient setting.
Eicher, Manuela, Zemp, Elisabeth, Krähenbühl, K., Fölmli, L., Rodmann, S., Rodmann, Susanne, Kurth, E., Eicher, M., Conzelmann, C., Krähenbühl, Katrin, Fölmli, Luzia, Conzelmann, Cornelia, Zemp, E., Kurth, Elisabeth   +13 more
core   +3 more sources

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

The timing of maternal depressive symptoms and child cognitive development: a longitudinal study. [PDF]

, 2012
16/01/12 meb. Publisher pdf attached ok to pub. open online.Background: Maternal depression is known to be associated with impairments in child cognitive development, although the effect of timing of exposure to maternal depression is unclear.
Heron, J, Murray, L, Ramchandani, P, Stein, A, Evans, Jonathan, Murray, Lynne, Heron, Jon, Wiles, N, Evans, J, Stein, Alan, Wiles, Nicola, Melotti, Roberto, Melotti, R, Ramchandani, Paul   +13 more
core   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Postnatal development of depth-dependent collagen density in ovine articular cartilage [PDF]

, 2010
Articular cartilage (AC) is the layer of tissue that covers the articulating ends of the bones in diarthrodial joints. Adult AC is characterised by a depth-dependent composition and structure of the extracellular matrix that results in depth-dependent ...
Kranenbarg, S., Leeuwen, J.L., van, Barend van Lagen, Turnhout, van, M.C.; id_orcid, Han Zuilhof, van Leeuwen, J.L., Turnhout, van, M.C., Turnhout, M.C., van, van Lagen, B., Henk Schipper, van Turnhout, M.C., Schipper, H., Leeuwen, van, J.L., Turnhout, MC Mark van, Lagen, van, B., Schipper, H, Leeuwen, JL Johan van, Lagen, B., van, Zuilhof, Han, Zuilhof, H., Mark C van Turnhout, Sander Kranenbarg, Lagen, B van, Kranenbarg, S, Johan L van Leeuwen   +24 more
core   +2 more sources

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

Evaluating a new course in postnatal care

, 2002
An innovative course has been developed and implemented to enable midwives to extend their role in the postnatal period. This is in response to the challenge for midwives to enhance their public health role.
Mitchell, Mary, Doyle, Mary
core   +1 more source