Results 91 to 100 of about 396,798 (317)

Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of age

, 2012
Background Studies of prenatal exposure to sex steroid hormones predict autistic traits in children at 18 to 24 and at 96 months of age. However, it is not known whether postnatal exposure to these hormones has a similar effect.
Simon Baron-Cohen, Kevin Taylor, Thomson, Lynn, O’donnell, Kieran J, Jag Ahluwalia, Bonnie Auyeung, Thomson Lynn, Hackett Gerald, Lynn Thomson, Gerald Hackett, Ahluwalia Jag, Hackett, Gerald, Ahluwalia, Jag, Baron-cohen, Simon, O’Donnell Kieran J, Auyeung Bonnie, Kieran J O’Donnell, Baron-Cohen Simon, Auyeung, Bonnie; id_orcid, Taylor, Kevin, Taylor Kevin   +20 more
core   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Farm and Animal Factors Associated with Morbidity, Mortality, and Growth of Pre-Weaned Heifer Dairy Calves in Southern Brazil

Animals
This study investigates morbidity, mortality, and weight gain in pre-weaned female dairy calves, which pose economic and animal welfare challenges for farms, particularly in family-run operations in southern Brazil.
Gabriela Olmos Antillón, Vilmar Fruscalso, Maria José Hötzel   +2 more
doaj   +1 more source

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source

Hippocampal Proteomics Reveals the Novel Molecular Profiling of Postnatal Lead (Pb) Exposure on Autism-like Behaviors

Toxics
Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental disorder, with lead (Pb) exposure increasingly linked to its risk. However, the molecular mechanisms linking Pb to ASD remain poorly understood.
Li Liu, Xulan Zhou, Zihan Ma, Ruming Liu, Yuhan Zhang, Yaqi Wang, Yiwen Liu, Xiaochun Xia, Juan Wang   +8 more
doaj   +1 more source

Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study

Brain and Behavior, 2020
Background Accumulating evidence suggests that breastfeeding exclusivity and duration are positively associated with child cognition. This study investigated whether DNA methylation, an epigenetic mechanism modified by nutrient intake, may contribute to ...
Rachael M. Taylor, Roger Smith, Clare E. Collins, David Mossman, Michelle W. Wong‐Brown, Eng‐Cheng Chan, Tiffany‐Jane Evans, John R. Attia, Nick Buckley, Karen Drysdale, Tenele Smith, Trent Butler, Alexis J. Hure   +12 more
doaj   +1 more source

POSTNATAL CHEMOPROPHYLAXIS [PDF]

Journal of Paediatrics and Child Health, 1991
J M, Hutson, A A, Woodward, S W, Beasley, J H, Kelly, R, Fowler, H L, Tan   +5 more
openaire   +2 more sources

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Distinct Impacts of Prenatal and Postnatal Phthalate Exposure on Behavioral and Emotional Development in Children Aged 1.5 to 3 Years

Toxics
Development is a continuous process, but few studies have assessed the simultaneous impact of prenatal and postnatal phthalate exposure on children’s behavioral and emotional development.
Yi-Siang Huang, Pi-Lien Hung, Liang-Jen Wang, Chih-Min Tsai, Chang-Ku Tsai, Mao-Meng Tiao, Hong-Ren Yu   +6 more
doaj   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source