Results 71 to 80 of about 396,798 (317)

Dietary Iron Deficiency Impaired Peripheral Immunity but Did Not Alter Brain Microglia in PRRSV-Infected Neonatal Piglets

Frontiers in Immunology, 2019
During the postnatal period the developing brain is vulnerable to insults including nutrient insufficiency and infection that may lead to disrupted development and cognitive dysfunction.
Brian J. Leyshon, Peng Ji, Megan P. Caputo, Stephanie M. Matt, Rodney W. Johnson, Rodney W. Johnson, Rodney W. Johnson   +6 more
doaj   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

The timing of maternal depressive symptoms and child cognitive development: a longitudinal study. [PDF]

, 2012
16/01/12 meb. Publisher pdf attached ok to pub. open online.Background: Maternal depression is known to be associated with impairments in child cognitive development, although the effect of timing of exposure to maternal depression is unclear.
Heron, J, Murray, L, Ramchandani, P, Stein, A, Evans, Jonathan, Murray, Lynne, Heron, Jon, Wiles, N, Evans, J, Stein, Alan, Wiles, Nicola, Melotti, Roberto, Melotti, R, Ramchandani, Paul   +13 more
core   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Evaluating a new course in postnatal care

, 2002
An innovative course has been developed and implemented to enable midwives to extend their role in the postnatal period. This is in response to the challenge for midwives to enhance their public health role.
Mitchell, Mary, Doyle, Mary
core   +1 more source

Differential expression of synaptophysin and synaptoporin during pre- and postnatal development of the hippocampal network [PDF]

, 1994
The closely related synaptic vesicle membrane proteins synaptophysin and synaptoporin are abundant in the hippocampal formation of the adult rat. But the prenatal hippocampal formation contains only synaptophysin, which is first detected at embryonic day
M. Gratzl, Grabs, D., Fox, P. A., M. Brich, Brich, M., D. Grabs, M. Bergmann, Bergmann, M., Gratzl, Manfred, Schuster, Th., Th. Schuster, P. A. Fox   +11 more
core   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Evaluating the use of corticosteroids in preventing and treating bronchopulmonary dysplasia in preterm neonates

International Journal of General Medicine, 2018
Oreoluwa Olaloko,1 Raihan Mohammed,1 Utkarsh Ojha2 1Faculty of Medicine, University of Cambridge, Cambridge, UK; 2Faculty of Medicine, Imperial College, London, UK Abstract: Approximately 15 million babies worldwide are born premature, and complications ...
Olaloko O, Mohammed R, Ojha U
doaj  

Factors associated with lack of postnatal care among Palestinian women: a cross-sectional study of three clinics in the West Bank

, 2008
Dhaher E, Mikolajczyk RT, Maxwell AE, Krämer A. Factors associated with lack of postnatal care among Palestinian women: a cross-sectional study of three clinics in the West Bank. BMC Pregnancy and Childbirth.
Krämer Alexander, Maxwell Annette E, Dhaher, Enas, Maxwell, Annette E., Mikolajczyk, Rafael T, Maxwell, Annette E, Krämer, Alexander ; https://orcid.org/, Annette E Maxwell, Alexander Krämer, Krämer, Alexander, Mikolajczyk Rafael T, Mikolajczyk, Rafael T., Dhaher Enas, Enas Dhaher, Rafael T Mikolajczyk   +14 more
core   +1 more source