Results 71 to 80 of about 4,270,416 (296)

Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction

Advanced Science, EarlyView.
In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng, Qian Zhu, Yusong Wang, Hao Rong, Xu Zhang, Fuchun Wang, Tianqi Yu, Wenxuan Wang, Jing Li, Lei Tian, Menghui Liao, Renjie Chai, Yangnan Hu   +12 more
wiley   +1 more source

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, EarlyView.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source

How should we perform neonatal mask ventilation during MR SOPA corrective steps?

Resuscitation Plus, 2023
Lukas P. Mileder, Michael Wagner, Maxi Kaufmann, Vincent D. Gaertner, Christoph M. Rüegger, Laila Springer   +5 more
doaj   +1 more source

An exploration of midwives' experiences and practice in relation to the assessment of maternal postnatal genital tract health [PDF]

Over the past 15 years the focus of postnatal care has changed. Contemporary professional guidance no longer directs midwives to undertake specific assessment tasks in relation to women’s genital tract, but advocates an holistic and individualised ...
Larkin, Valerie
core  

Postnatal depression and reproductive success in modern, low-fertility contexts [PDF]

, 2015
Background and objectives: Postnatal depression (PND) presents a puzzling phenomenon to evolutionary anthropologists as it is highly prevalent and yet detrimental to child development and maternal health.
Sarah E. Johns, Myers, Sarah, Johns, Sarah E., Sarah Myers, Burger, Oskar F., Oskar Burger   +5 more
core   +3 more sources

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

Parental smoking and children's respiratory health: independent effects of prenatal and postnatal exposure. [PDF]

, 2006
OBJECTIVES: Adverse effects have been reported of prenatal and/or postnatal passive exposure to smoking on children's health. Uncertainties remain about the relative importance of smoking at different periods in the child's life. We investigate this in a
Hruba, F., Zlotkowska, Renata, Privalova, L., Janssen, Nicole, Splichalova, A., Heinrich, Joachim, Pattenden, S., Splichalova, Anna, Rudnai, Peter, Neuberger, M., De Sario, Manuela, Heinrich, J., Nikiforov, B., Luttmann-Gibson, Heike, Neuberger, Manfred, Antova, Temenuga, Luttmann-Gibson, H., Privalova, Larissa, Pattenden, Sam, Nikiforov, Bojidar, Fletcher, T., Grize, Leticia, Antova, T., Hruba, Frantiska, de Sario, M., Janssen, N., Fletcher, Tony, Rudnai, P., Grize, L., Zlotkowska, R.   +29 more
core   +1 more source

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

The postnatal support needs of mothers with an intellectual disability [PDF]

, 2013
OBJECTIVE: there is growing evidence that many parents with intellectual disabilities can parent successfully when given adequate support. This paper aims to explore the postnatal care experiences of mothers with an intellectual disability.
McKenzie, Karen, Wilson, Suzanne, Quayle, Ethel, Murray, George   +3 more
core   +1 more source