Results 31 to 40 of about 1,208,324 (319)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

pH as a potential therapeutic target to improve temozolomide antitumor efficacy : A mechanistic modeling study

Pharmacology Research & Perspectives, 2019
Despite intensive treatments including temozolomide (TMZ) administration, glioblastoma patient prognosis remains dismal and innovative therapeutic strategies are urgently needed.
Angélique Stéphanou, Annabelle Ballesta   +1 more
doaj   +1 more source

Spondylodiscitis: evaluation of patients in a tertiary hospital

Journal of Infection in Developing Countries, 2014
Introduction: Spondylodiscitis (SD) is an uncommon but important infection. The aim of this work was to study the risk factors, bacteriological features, clinical, laboratory and radiological findings of SD, and to shed light on the initial treatment ...
Safak Kaya, Serdar Ercan, Sehmuz Kaya, Ulas Aktas, Kagan Kamasak, Hakan Ozalp, Kadir Cinar, Recai Duymus, Mehmet Gazi Boyaci, Nesrin Akkoyun, Ahmet Emre Eskazan, Hakan Temiz   +11 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Survival after postoperative morbidity: a longitudinal observational cohort study. [PDF]

, 2014
BACKGROUND: Previous studies have suggested that there may be long-term harm associated with postoperative complications. Uncertainty exists however, because of the need for risk adjustment and inconsistent definitions of postoperative morbidity. METHODS:
Harris, S, Rowan, KM, Moonesinghe, S.R., Emberton, M., Harris, S., Haddad, FS, Mythen, MG, Haddad, F.S., Moonesinghe, SR, Emberton, M, Grocott, MP, Grocott, M.P.W., Rowan, K.M., Grocott, MPW, Mythen, M.G.   +14 more
core   +1 more source

Risk factors associated with postoperative complications and prolonged postoperative length of stay after laparoscopic liver resection

, 2022
INTRODUCTION: Laparoscopic liver resection (LLR) has expanded rapidly. Previously published studies are limited to small samples and selected patients. Comprehensive data that may significantly influence the incidence of perioperative complications and ...
Wei Zhang, Li, Bo, Liu, Fei, Wei, Yonggang, Yonggang Wei, Bo Li, Zhang, Wei, Fei Liu, Kang, Dufu, Haili Zhang, Zhang, Haili, Dufu Kang   +11 more
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Postoperative hypophosphataemia

Journal of British Surgery, 1979
Summary The possible mechanisms of postoperative hypophosphataemia were studied in women undergoing uncomplicated cholecystectomy. Six patients were allocated to each of three groups. Group I received no intravenous fluids, group II received dextrose/saline solution alone and group III received dextrose/saline solution with phosphorus ...
P C, England, M, Duari, D E, Tweedle, R A, Jones, E, Gowland   +4 more
openaire   +2 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Postoperative Tetanus [PDF]

Southern Medical Journal, 1910
n ...
openaire   +1 more source