Results 121 to 130 of about 142,335 (242)

Integrated ‘Shield‐Spear’ Biological Patch for Fibrosis‐Free Bladder Reconstruction

Advanced Science, EarlyView.
Fibrosis‐free bladder reconstruction remains challenging. This study pioneers an integrated “shield‐spear” patch: The outer anionic hydrogel layer captures GATA6+ macrophages to suppress collagen overexpression, while the inner S100 aptamer‐engineered EVs target Schwann cells to downregulate the TGFβ/Smad pathway—inhibiting fibrosis with enhanced wound
Xiaoqi Wu, Huitong Ruan, Xiaolin Zhang, Weihan Zheng, Muhetaierjiang Mutailifu, Ling Wang, Liu Yu, Ruijun Peng, Rui Zhao, Zihan Wang, Jie Xu, Shaochuan Li, Yaobin Wu, Wenguo Cui, Mujun Lu   +14 more
wiley   +1 more source

NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex

Advanced Science, EarlyView.
The primary neurological manifestations of tuberous sclerosis complex (TSC) are intractable epilepsy and intellectual disability. NEAT1 is differentially expressed in TSC‐related epilepsy and influences neuronal excitability by regulating the PI3K/AKT/mTOR signaling pathway.
Suhui Kuang, Tinghong Liu, Zhirong Wei, Jinshan Xu, Jiayi Han, Jiaqi Wang, Feng Zhai, Yiran Tian, Shuli Liang   +8 more
wiley   +1 more source

Estancia hospitalaria de pacientes con antibioticoterapia por infecciones posoperatorias

Medisan
Se realizó un estudio descriptivo, de serie de casos, de 258 pacientes intervenidos de forma urgente o electiva durante el trienio 2012-2014 en el Servicio de Cirugía General del Hospital Provincial Docente Clinicoquirúrgico "Saturnino Lora Torres" de ...
Zenén Rodríguez Fernández, Olga Fernández López, Lázaro Ibrahím Romero García   +2 more
doaj  

Evaluating a trainee’s progress in surgical dexterity [PDF]

, 2005
The local cardiac surgical training program is modelled on a one-to-one apprenticeship encompassing a number of years. Trainee progress is regularly audited and work of increasing complexity is provided, commensurate with the trainee's ability. Speed and
Manche, Alexander, Schembri, Kevin
core  

EETs Reduction Contributes to Granulosa Cell Senescence and Endometriosis‐Associated Infertility via the PI3K/AKT/mTOR Signaling Pathway

Advanced Science, EarlyView.
1) 14, 15‐EET levels were decreased in ovarian granulosa cells, follicular fluid, peritoneal fluid from endometriosis patients. 2) EETs reduction in endometriosis follicular fluid aggravated granulosa cell senescence. 3) ROS reduced 14, 15‐EET levels by upregulating EPHX2 through a mechanism involving histone methylation modification.
Xiang Lin, Weijia Gu, Xiaomei Tong, Mengru Lai, Yi Zhang, Na Liu, Xiaoying Jin, Chao Li, Dong Huang, Feng Zhou, Yongdong Dai, Songying Zhang   +11 more
wiley   +1 more source

CSF markers for diagnosis of bacterial meningitis in neurosurgical postoperative patients

Arquivos de Neuro-Psiquiatria, 2006
OBJECTIVE: To evaluate the diagnostic usefulness of cerebral spinal fluid (CSF) cellularity, protein, neutrophils, glucose and lactate for detection of postoperative bacterial meningitis.
Tavares Wagner Malagó, Machado Andre Guelman, Matushita Hamilton, Plese Jose Pindaro P.   +3 more
doaj  

Megasphaera Elesdenii Dysregulates Colon Epithelial Homeostasis, Aggravates Colitis‐Associated Tumorigenesis

Advanced Science, EarlyView.
A fecal microbial meta‐analysis reveals that Megasphaera is highly abundant in the Asian population with IBD and CRC. M. elsdenii reshapes colonic immunity by triggering DC cell‐mediated Th1 and Th17 inflammation. M. elsdenii and M. elsdenii‐enriched microbiota exacerbate colonic inflammation and tumorigenesis in AOM/DSS mice.
Xinxin Hou, Zhaozhou Zhang, Wanqing Chen, Jinming Li, Xiangxiang Zhu, Mingjie Li, Xiaoqi Guan, Haidong Guo, Yanlei Ma, Ling Zhao   +9 more
wiley   +1 more source

HMGB2 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through MTA2‐Driven Metabolic Reprogramming

Advanced Science, EarlyView.
In contrast to the adult mammalian heart, which lacks regenerative capacity, the neonatal heart retains a transient regenerative capacity. In this study, high mobility group box 2 (HMGB2) is identified as a crucial protein driving heart regeneration based on comprehensive analyses using quantitative proteomics with tandem mass tag (TMT) labelling, RNA ...
Liu‐Hua Zhou, Ling‐Feng Gu, Yi‐Xi Chen, Peng Jing, Tong‐Tong Yang, Ye He, Yu‐Lin Bao, Xiang‐Zheng Zhang, Chong Du, Si‐Bo Wang, Tian‐Kai Shan, Jia‐Yi Chen, Hao Wang, Qi‐Ming Wang, Li‐Ping Xie, Yang Zhao, Yong Ji, Lian‐Sheng Wang   +17 more
wiley   +1 more source

The Composite Antiadhesion Barrier Facilitated Fibroblast Autophagy Activation for Tendon Repair

Advanced Science, EarlyView.
Synthesis of an innovative three‐layer composite antiadhesion barrier (plasmid DNA@E–H–E′) is schematically illustrated, highlighting its reactive‐oxygen‐species‐responsive, unidirectional interleukin‐37 delivery to enhance fibroblast autophagy, thereby effectively preventing tendon adhesion and promoting scarless tendon repair.
Zhenyu Sun, Jingwen Liu, Liang Chen, Zhen Wang, Fei Wang, Shen Liu   +5 more
wiley   +1 more source

Sono‐Controllable Janus Hydrogel Platform for Sequential Tumor Eradication and Bone Regeneration in Metastatic Breast Cancer

Advanced Science, EarlyView.
Sequential tumor eradication and bone regeneration remain a significant challenge for patients with breast cancer bone metastases. This study develops a novel Janus hydrogel platform, which can achieve tumor elimination and bone repair under the action of different ultrasound frequencies.
Yitong Li, Yunyun Liu, Chuyun Lou, Xuejun Chen, Ying Zhang, Hui Shi, Jiayi Qiu, Shen Zhang, Taixia Wang, Xiaowei Wang, Haohao Yin, Huixiong Xu, Yifeng Zhang   +12 more
wiley   +1 more source