Results 61 to 70 of about 330,067 (262)

Relationship between serum level of procalcitonin,erythrocyte sedimentation rate and postoperative infection among middle⁃aged and elderly patients after spinal surgery

Huli yanjiu, 2022
ObjectiveTo explore between serum level of procalcitonin（PCT），erythrocyte sedimentation rate（ESR） and postoperative infection among middle⁃aged and elderly patients after spinal surgery.Methods158 patients who underwent spinal surgery in our hospital ...
ZENG Guohua, CHEN Rongchun, WU Qiong, JIANG Manxiang   +3 more
doaj  

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Control strategies to prevent total hip replacement-related infections: a systematic review and mixed treatment comparison

, 2014
Objective: To synthesise the available evidence and estimate the comparative efficacy of control strategies to prevent total hip replacement (THR)-related surgical site infections (SSIs) using a mixed treatment comparison.\ud Design: Systematic review ...
Cooper, N, H. Zheng (2057848), K. Merollini (7697756), Merollini, Katharina, Wilson, Jennie, Zheng, H, Berendt, T, Graves, Nicholas, Wilson, Jennie A., Nicola Cooper (698917), T. Berendt (7697759), Berendt, Tony, Zheng, Henry, Barnett, Adrian G., Sutton, A, Cooper, Nicola, J. Wilson (4917331), Barnett, A G, A. G. Barnett (7697753), Alex Sutton (11700), Graves, N, Wilson, J, N. Graves (7697762), Zhang, Henry, Sutton, Alex   +24 more
core   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Distraction osteogenesis of the mandible: does postoperative infection affect stability?

, 2017
Background: Up to the present time, no study has attempted to explore a possible association between skeletal stability and postoperative infection in mandibular advancement by distraction osteogenesis.
W.S. Choi, T.S. Li, Li, TS, Choi, WWS
core   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Discriminatory power of biomarkers for postoperative infection.

, 2015
PSP levels showed a significantly stronger postoperative rise at day 1–3 in patients receiving a diagnosis of infection during their hospital stay as opposed to patients exhibiting an uneventful course ...
Ksenija Slankamenac (707739), Hector Rodriguez Cetina Biefer (707741), Felix Schönrath (707740), Alain Rudiger (124208), Rolf Graf (19984), Christoph T. Starck (707742), Holger J. Klein (707737), Adam Csordas (707738), Volkmar Falk (393287)   +8 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Preventing and treating surgical site infection in patients with spinal metastatic disease

, 2013
Surgery to remove secondary spinal tumours is often necessary to relieve symptoms associated with metastatic spinal cord compression (MSCC). However, such individuals are at high risk of surgical site infection (SSI).
Lui, Steve, Atkinson, Ross, Ousey, Karen
core  

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source