Results 21 to 30 of about 373,401 (268)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Comparison of postoperative pain according to the harvesting method used in hair restorative surgery

Archives of Plastic Surgery, 2019
Background Postoperative pain is one of the most common concerns of patients undergoing hair transplantation surgery. Because most patients are satisfied with the cosmetic improvement after transplantation, amelioration of postoperative pain would help ...
Yang Seok Kim, Young Cheon Na, Jae Hyun Park   +2 more
doaj   +1 more source

The Case of a 28‐Year‐Old Woman With Medically Refractory Focal Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We present the case of a 28‐year‐old right‐handed woman with medically refractory focal epilepsy. Her seizure semiology and electroencephalography (EEG) indicated a seizure onset zone in the right central‐parietal area. However, both MRI and PET scans were unremarkable, showing no focal lesions or areas of altered metabolism.
Rishi Sharma, Ilo Leppik, Thomas Henry, Thaddeus Walczak, Sima Patel, Robert McGovern   +5 more
wiley   +1 more source

A Scoping Review on Artificial Intelligence–Supported Interventions for Nonpharmacologic Management of Chronic Rheumatic Diseases

Arthritis Care &Research, EarlyView.
This review summarizes artificial intelligence (AI)‐supported nonpharmacological interventions for adults with chronic rheumatic diseases, detailing their components, purpose, and current evidence base. We searched Embase, PubMed, Cochrane, and Scopus databases for studies describing AI‐supported interventions for adults with chronic rheumatic diseases.
Nirali Shah, Alexis Castellanos, Yen Chen, John Piette, Amy Bucher, Susan Murphy   +5 more
wiley   +1 more source

Influence of different patient positions on erector spinae plane block spread in modified radical mastectomy: a prospective randomized comparative study

BMC Anesthesiology
Background Although the analgesic effect of erector spinae plane block (ESPB) has been proven, its efficacy may be influenced by the patient’s position during the block.
Adel Ibrahim Hozien, Sahar Ahmed Elkaradawy, Hussein M. Agameya, Walid M. Ahmed, Ahmed F. Elsosy   +4 more
doaj   +1 more source

Use of a Molecular Signature Response Classifier to Inform Treatment Selection Improves Clinical Disease Activity Among Patients with Rheumatoid Arthritis Initiating a Biologic or Targeted Synthetic Disease‐modifying Antirheumatic Drug

Arthritis Care &Research, Accepted Article.
Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD) Methods PrismRA incorporated 19 gene expression features and 4 clinical features to assess a patient's likelihood of ...
Fenglong Xie, Timothy Beukelman, Nicholas P McCormick, Jeffrey R Curtis   +3 more
wiley   +1 more source

Transcranial Color Doppler for Assessing Cerebral Venous Outflow in Critically Ill and Surgical Patients

Diagnostics
In recent years, Transcranial Color Doppler (TCCD) has gained increasing recognition as a non-invasive neuromonitoring tool. However, there remains a strong tendency to view arterial TCCD as the ‘stethoscope for the brain,’ while the assessment of ...
Amedeo Bianchini, Giovanni Vitale, Gabriele Melegari, Matteo Cescon, Matteo Ravaioli, Elena Zangheri, Maria Francesca Scuppa, Stefano Tigano, Antonio Siniscalchi   +8 more
doaj   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Pain severity scale: A methodology for classifying postoperative pain severity by surgical procedure

Surgery Open Science, 2023
Background: Acute postoperative pain is common following many types of surgery, and a significant subset of patients experience severe pain, which can be difficult to manage and result in postoperative complications.
James Hitt, Robert Lee, Peter Elkin
doaj   +1 more source

Preemptive effects of etoricoxib, acetaminophen, nimesulide, and ibuprofen on postoperative pain management after single‐implant surgery: A randomized clinical trial [PDF]

, 2023
Gustavo Henrique Mattos Pereira, Rafael Paschoal Esteves Lima, Luís Otávio Miranda Cota, Rachel Alvarenga‐Brant, Fernando Oliveira Costa   +4 more
openalex   +1 more source