Results 31 to 40 of about 565 (205)

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Screening Acuracy of the Portuguese Version of the Postpartum Depression Screening Scale

European Psychiatry, 2009
Screening for postpartum depression has been considered essential. The Postpartum Depression Screening Scale (PDSS; Beck & Gable, 2002) is a self-report instrument, composed of 35 items placed in the specific context of new maternity. The aim of the present study was to determine, for the first time, PDSS cut-off points (adjusted to the real ...
A. Pereira, S. Bos, B. Maia, M. Marques, M.J. Soares, A. Gomes, J. Valente, A. Macedo, M.H. Azevedo   +8 more
openaire   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Supporting routine cognitive reactivity assessment during the perinatal period: psychometric testing of the Chinese version of the Leiden Index of Depression Sensitivity

BMC Pregnancy and Childbirth, 2022
Background It is critical to find optimal forms to identify perinatal depression (PND) and its vulnerable factors and make them more applicable to depression screening.
Yanqing Fu, Yu-an Lin, Jiansheng Zheng, Huilan Hong, Songqing Huang, Jiang Li, Feifei Huang   +6 more
doaj   +1 more source

Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation

Advanced Science, EarlyView.
This study presents a scalable all‐electrical method for precise neuronal‐circuit reconfiguration based on high‐density microelectrode arrays. By employing biologically inspired plasticity rules, targeted connectivity changes were successfully induced and quantified across diverse neuronal preparations.
Sreedhar S. Kumar, Yannaël Bossard, Rachel Sava, Tobias Gänswein, Lorenca Sadiraj, Jean‐Samuel Dupré, Manuel Schröter, J. Gray Camp, Fernando Cardes, Julian Bartram, Andreas Hierlemann   +10 more
wiley   +1 more source

Postpartum depression and its association with social support: a cross sectional study at a maternity hospital in Kerala.

Kerala Journal of Psychiatry, 2020
Background: Childbirth is associated with significant physiological changes as well as challenges related to psychiatric disorders. Postpartum depression (PPD) is one such condition associated with high levels of morbidity and mortality.
Kuriakose Santhosh , S Vinaychandran, K T P Dayal Narayan, C H Mini   +3 more
doaj   +3 more sources

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Screening for individuals with postpartum depression by an attenuated and delayed niacin skin flushing response: a case control study

BMC Pregnancy and Childbirth
Background Postpartum depression (PPD) affects maternal mental health extensively and is challenged by the lack of objective diagnostic methods. This study aimed to explore the characteristics of niacin skin flush response, a diagnostic marker for ...
Dandan Wang, Yan Gao, Zhendong Xu, Fuyi Shen, Xiaowen Hu, Xuhan Yang, Qian Wang, Juan Zhang, Jie Jiang, Yan Zhuang, Lize Xiong, Jun Li, Chunling Wan, Zhiqiang Liu   +13 more
doaj   +1 more source

Postpartum depression and thyroid dysfunction– should pregnant women be screened for thyroid disorders?

Journal of Mind and Medical Sciences, 2019
The relationship between thyroid dysfunction and postpartum depression has been investigated for quite some time now, but no consensus has been reached regarding the need for screening for thyroid function during pregnancy. This paper aims to investigate
Anca A. Simionescu, Erika Marin
doaj   +1 more source

Clinical, Behavioral and Neuroradiological Phenotype in an Italian Cohort of Patients With Xia Gibbs Syndrome: A Multicenter Cross‐Sectional Study and Systematic Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous variants in the AHDC1 gene are associated with Xia Gibbs Syndrome (XGS), a genetic disorder with a highly variable phenotype. Cognitive impairment, motor delay, language delay, neonatal hypotonia, and sleep apnea are considered “cardinal” signs of the disease.
Giulia Cinelli, Stefania Della Vecchia, Patrizia Bergonzini, Elisa Caramaschi, Elisabetta Spezia, Claudia Parenti, Simona Filomena Madeo, Laura Lucaccioni, Cavalleri Francesca, Marisa Pugliese, Federico Raviglione, Clara Colonna, Olga Calabrese, Ilaria Stanghellini, Maria Carmen Marongiu, Enrico Biagioni, Anna Rita Ferrari, Roberta Battini, Lorenzo Iughetti   +18 more
wiley   +1 more source