Results 51 to 60 of about 598,095 (304)

Subventricular Zone‐on‐a‐Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage

Advanced Science, EarlyView.
A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni, Begüm Gökçe, Magnus Gram, Coco Holliday, Aylin Sendemir, Marimélia Aparecida Porcionatto, Anna Herland   +6 more
wiley   +1 more source

The association between maternal vitamin D deficiency and postpartum hemorrhage and uterine atony

Acta Obstetricia et Gynecologica Scandinavica
Introduction Postpartum hemorrhage is the leading cause of maternal morbidity and mortality worldwide. There are several known risk factors for postpartum hemorrhage related to pregnancy and delivery, but less evidence of predisposing factors.
Anna Sörsjö Stevenazzi, Sofia Pihl, Marie Blomberg, Daniel Axelsson   +3 more
doaj   +1 more source

Machine Learning and Statistical Models to Predict Postpartum Hemorrhage.

Obstetrics and Gynecology, 2020
OBJECTIVE To predict a woman's risk of postpartum hemorrhage at labor admission using machine learning and statistical models. METHODS Predictive models were constructed and compared using data from 10 of 12 sites in the U.S.
M. P. Kartik K. Venkatesh, Robert A. Strauss PhD, C. A. Md, M. R. P. Md, MD Nancy C. Chescheir, J. S. A. Md, D. M. Md, M. K. M. Md, M. J. E. Md   +8 more
semanticscholar   +1 more source

Vacuum-Induced Tamponade for Treatment of Postpartum Hemorrhage

Obstetrics and Gynecology, 2021
Vacuum-induced tamponade appears to be an easy-to-use, promising method for the treatment of postpartum hemorrhage, particularly in women with uterine atony.
C. Haslinger, K. Weber, R. Zimmermann
semanticscholar   +1 more source

Continuous Suppression of Pathological Retinal and Choroidal Neovascularization in Cynomolgus Monkeys via Noninvasive Ophthalmic Delivery of a Novel Anti‐VEGFA Nanobody and Proprietary Penetratin Analog Formulation

Advanced Science, EarlyView.
Pathological retinal/choroidal neovascularization drives vision loss in DR and AMD. Current anti‐VEGF injections, while effective, require invasive, frequent administration. Pene/LQ015, is developed a novel topical anti‐VEGFA nanobody formulation achieving therapeutic intraocular levels through penetratin analog‐enhanced delivery.
Chong Chen, Min Zhu, Xingyan Fan, Kangjia Lv, Kuan Jiang, Yuchen Zhang, Haoliang Zhang, Xinming Qi, Benjamin TK Lee, Yakun Wan, Gang Wei, Kun Liu, Xun Xu   +12 more
wiley   +1 more source

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

Advanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo, Haiying Zhou, Lihai Gong, Luowei Yuan, Yang Fu, Yulong Qiao, Ying Lam Lui, Nuo Chen, Pengfei Lin, Hoi Hung Cheung, Ho Ko, Linyan Meng, Xiao Chen, Yong Lei, Kin Ming Kwan, Huating Wang, Shen Gu   +18 more
wiley   +1 more source

Viscoelastic Hemostatic Assays for Postpartum Hemorrhage

Journal of Clinical Medicine, 2021
This article discusses the importance and effectiveness of viscoelastic hemostatic assays (VHAs) in assessing hemostatic competence and guiding blood component therapy (BCT) in patients with postpartum hemorrhage (PPH).
A. Liew-Spilger, Nikki R Sorg, Toby J Brenner, J. Langford, Margaret Berquist, Natalie M Mark, Spencer H Moore, J. Mark, S. Baumgartner, M. Abernathy   +9 more
semanticscholar   +1 more source

IPGCA: A Comprehensive Single Cell Atlas of 1 074 127 Porcine Intestinal Cells Revealing Cellular Dynamics, Genetic Regulation, and Cross‐Species Conservation

Advanced Science, EarlyView.
A high resolution integrated cell atlas of the pig intestine provides insights into the genetic mechanisms of complex traits (Created in BioRender. Yu, P. (2025) https://BioRender.com/o14c563) Abstract The porcine intestinal tract is vital for nutrient absorption, immune regulation, and various physiological processes.
Pengfei Yu, Qinqin Xie, Xiaodian Cai, Zhanming Zhong, Ran Wei, He Han, Shuang Liu, Zhenyang Zhang, Lingyao Xu, Zitao Chen, Zhe Zhang, Qishan Wang, Yuchun Pan, Zhen Wang, Zhe Zhang   +14 more
wiley   +1 more source

Anemia during pregnancy and its influence on postpartum hemorrhage

Medisains
Background: Up to 50% of pregnant women in low-income and middle-income countries are affected by anemia, and 30.43% of maternal deaths in Indonesia occur during the postpartum period.
Syamsuriyati Syamsuriyati, Rika Handayani, Sunartono Suhartono, Sutriani Syarif, Nurhidayat Triananinsi   +4 more
doaj   +1 more source

Phospholipid Remodeling and Tri‐Layer Membrane Reconstruction Mediate Cognitive Effects of Humanized Milk Fat Globules in Neonatal Rats

Advanced Science, EarlyView.
Humanized milk fat globules (MFG) mimic the native composition and structure of human milk, achieved through remodeling of milk fat globule membrane phospholipid composition and reconstruction of the tri‐layer membrane structure. These humanized MFG exhibit improved structural stability and digestibility, and enhance neurodevelopment in formula‐fed rat
Shaolei Wang, Fengzhi Qiao, Jian He, Jianxin Fu, Tongjie Liu, Huaxi Yi, Qinghai Sheng, Lanwei Zhang, Kai Lin   +8 more
wiley   +1 more source