Results 131 to 140 of about 71,707 (290)

Pharmacokinetics, pharmacodynamics and safety of casdatifan, a novel hypoxia‐inducible factor‐2α inhibitor, in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims Casdatifan is an orally bioavailable small‐molecule hypoxia‐inducible factor‐2α (HIF‐2α) inhibitor currently in development for treating patients with clear cell renal cell carcinomas. The aim of this study was to characterize the pharmacokinetics (PK), pharmacodynamics and safety of casdatifan in healthy participants.
Mohammad Ghasemi, Ji Yun Kim, Lisa Seitz, Lixia Jin, Paul G. Foster, Kai H. Liao, Tzuling Cheng, Elaine Paterson, Maria Velinova, Nicole Rivera Rosario, Reza Khosravan, Balaji Agoram   +11 more
wiley   +1 more source

Angelica gigas extract inhibits acetylation of eNOS via IRE1α sulfonation/RIDD-SIRT1-mediated posttranslational modification in vascular dysfunction. [PDF]

Aging (Albany NY), 2023
Lee GH, Lee HY, Lim YJ, Kim JH, Jung SJ, Jung ES, Chae SW, Lee J, Lim J, Rashid MMU, Min KH, Chae HJ.   +11 more
europepmc   +1 more source

A first exon-encoded domain of E1A sufficient for posttranslational modification, nuclear-localization, and induction of adenovirus E3 promoter expression in Xenopus oocytes.

, 1985
Joel D. Richter, Paul R. Young, N C Jones, B Krippl, Martin Rosenberg, B Ferguson   +5 more
openalex   +1 more source

Cubilin expression and posttranslational modification in the canine gastrointestinal tract [PDF]

, 2000
Danbin Xu, John C. Fyfe
openalex   +1 more source

Coming to Terms: The Mechanisms of Overplus and Luxury Phosphorus Uptake for Polyphosphate Storage in Microalgae and Yeast

Biotechnology and Bioengineering, EarlyView.
Plouviez et al. give a perspective on the terminology used for describing the mechanisms of polyphosphate accumulation in microalgae and yeast. Their differentiation of mechanisms is based on environmental P availability, polyP chemistry, genetics, or cellular function as described in recent literature.
Maxence Plouviez, Philipp Demling, Alexander Deitert, Jana Fees, Makarius Baier, Tobias Karmainski, Lars M. Blank, Benoit Guieysse   +7 more
wiley   +1 more source

Protein Posttranslational Modification in Stemness Remodeling and Its Emerging Role as a Novel Therapeutic Target in Gastrointestinal Cancers. [PDF]

Int J Mol Sci, 2023
Wang Y, Tong M.
europepmc   +1 more source

Posttranslational Modifications of p53 in Replicative Senescence Overlapping but Distinct from Those Induced by DNA Damage [PDF]

, 2000
Katherine Webley, Jane Bond, Christopher J. Jones, Jeremy P. Blaydes, Ashley Craig, Ted R. Hupp, David Wynford‐Thomas   +6 more
openalex   +1 more source

Synthesis, In Silico, and Biological Evaluation of Non‐Hydroxamate Benzoic Acid–Based Derivatives as Potential Histone Deacetylase Inhibitors (HDACi)

Chemistry &Biodiversity, EarlyView.
Compound A3bn exhibited strong binding affinities for HDAC2, HDAC6, and HDAC8. A3bn’s anticancer IC50 values were similar to those of SAHA. Cell death resulted from the extrinsic apoptotic pathway. Compound A3bn, a hydrophilic linker, which promotes zinc coordination, may be the cause of its increased activity across HDAC isoforms. ABSTRACT Unregulated
Nedaa A. Abd Al Rahim, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Randa M. Bawadi, Ayah Y. Almasri, Marya A. Hamad, Nour A. Hussein, Salem R. Yasin, Abdulrahman M. Saleh   +8 more
wiley   +1 more source

Lactylation: a Passing Fad or the Future of Posttranslational Modification. [PDF]

Inflammation, 2022
Xin Q, Wang H, Li Q, Liu S, Qu K, Liu C, Zhang J.   +6 more
europepmc   +1 more source

Posttranslational modifications of recombinant myotube-synthesized human factor IX [PDF]

, 2001
Valder R. Arruda, James N. Hagstrom, Jeffrey S. Deitch, Terry Heiman‐Patterson, Rodney M. Camire, Kirk Chu, Paul Fields, Roland W. Herzog, Linda B. Couto, Peter J. Larson, Katherine A. High   +10 more
openalex   +1 more source