Results 141 to 150 of about 71,707 (290)

Interactions of Neurodegenerative Disease Positron Emission Tomography Imaging Probe Candidates with the C‐Terminus of α‐Synuclein Fibrils

ChemBioChem, EarlyView.
Binding studies of α‐synuclein (αS) fibril ligands using photo‐crosslinking mass spectrometry and Förster resonance energy transfer show that the multiple system atrophy (MSA)‐selective lead, HY‐215, interacts with the αS C‐terminus, unlike Parkinson's disease (PD)‐selective lead, M503. Thus, often‐ignored interactions with the disordered regions of αS
Kyle D. Shaffer, Ryann M. Perez, Marshall G. Lougee, Vinayak V. Pagar, Hee Jong Kim, Ho Young Kim, Benjamin A. Garcia, Robert H. Mach, E. James Petersson   +8 more
wiley   +1 more source

Enzymatic lysine oxidation as a posttranslational modification. [PDF]

FEBS J, 2022
Serra-Bardenys G, Peiró S.
europepmc   +1 more source

Posttranslational modification and subcellular localization of the p12 capsid protein of herpes simplex virus type 1

, 1992
David S. McNabb, Richard J. Courtney
openalex   +1 more source

Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site [PDF]

, 2001
Xue Du, Diane Edelstein, Stefanie Dimmeler, Qida Ju, Chengyu Sui, Michael Brownlee   +5 more
openalex   +1 more source

Unlocking Biomolecule Modification with Light‐Promoted Photocatalyst‐Free Approaches: Current Tools, Challenges, and Perspectives

ChemistryEurope, EarlyView.
This Perspective focuses on photocatalyst‐free, photoinduced modifications of biomolecules, emphasizing transformations mediated by electron donor–acceptor complexes. Mechanistic aspects, current limitations, and future opportunities are discussed, providing insight into the field of bioconjugation.
Milene Hornink, Maria Eduarda C. Thedy, Eugénie Romero, Gary A. Molander   +3 more
wiley   +1 more source

Editorial: Waken the Silent Majority: Principles and Pathogenic Significance of Non-Acetyl Acylation and Other Understudied Post-Translational Modifications

Frontiers in Cell and Developmental Biology, 2022
Fangliang Zhang, Fangliang Zhang
doaj   +1 more source

Status of treatment strategies for Hutchinson-Gilford progeria syndrome with a focus on prelamin: A posttranslational modification. [PDF]

Basic Clin Pharmacol Toxicol, 2022
Chen X, Yao H, Andrés V, Bergo MO, Kashif M.   +4 more
europepmc   +1 more source

Posttranslational side chain modification of a viral epitope results in diminished recognition by specific T cells

, 1992
J K Larson, L. Ötvös, Hildegund C.J. Ertl   +2 more
openalex   +1 more source

Metabolite‐Guided Acetylation Therapy: Astragaloside IV Reverses Diabetic Nephropathy via Gna13‐Driven Purine Metabolic Reprogramming

Food Frontiers, EarlyView.
This study unveils how ASIV reverses diabetic nephropathy by restoring Gna13‐K363 acetylation and reprogramming purine metabolism. Using spatial metabolomics and acetylproteomics, we identified zonation‐specific purine dysregulation in diabetic kidneys, with ASIV normalizing metabolite distribution (hypoxanthine, cAMP, guanine) and targeting Gna13 ...
Shi Qiu, Sifan Guo, Dandan Xie, Zhibo Wang, Ying Cai, Xian Wang, Qiang Yang, Chunsheng Lin, Hong Yao, Qiqi Zhao, Yu Guan, Songqi Tang, Yiqiang Xie, Aihua Zhang   +13 more
wiley   +1 more source

Fermentation of Soy Juice by Lactiplantibacillus plantarum CIRM‐BIA777 Produces Flavor‐Related and Health‐Promoting Metabolites

Food Frontiers, EarlyView.
Transcriptomics revealed the metabolism of Lactiplantibacillus plantarum during soy milk fermentation. The fermentation of soy milk released aroma compounds and health‐beneficial metabolites. ABSTRACT The fermentation of plant‐based beverages, such as organic and locally produced soy juice (SJ), offers a sustainable way to develop dairy alternatives ...
Olivier Harlé, Sandrine Parayre, Marie‐Bernadette Maillard, Gwenaële Henry, Éric Guédon, Anne Thierry, Jérôme Niay, Stéphanie‐Marie Deutsch, Hélène Falentin   +8 more
wiley   +1 more source