Results 161 to 170 of about 941,378 (248)

Angelica gigas extract inhibits acetylation of eNOS via IRE1α sulfonation/RIDD-SIRT1-mediated posttranslational modification in vascular dysfunction. [PDF]

Aging (Albany NY), 2023
Lee GH, Lee HY, Lim YJ, Kim JH, Jung SJ, Jung ES, Chae SW, Lee J, Lim J, Rashid MMU, Min KH, Chae HJ.   +11 more
europepmc   +1 more source

Tankyrase‐2 regulates adipocyte differentiation through AMPK/mTOR signaling

The FEBS Journal, EarlyView.
Tankyrase 2 (TNKS2), a PARP family member, underpins adipocyte differentiation. TNKS2 controls LKB1 protein level, and consequently, the activity of the mTOR/AMPK system and adipocyte differentiation through a layered process. Pharmacological inhibition of TNKS2 leaves other PARPs and DNA repair active and therefore represents a novel target in ...
Boglarka Rauch, Gyula Ujlaki, Szilard Poliska, Nakayi Murahwa, Patrik Kovacs, Aladar Pettko‐Szandtner, Karen Uray, Peter Bai   +7 more
wiley   +1 more source

Status of treatment strategies for Hutchinson-Gilford progeria syndrome with a focus on prelamin: A posttranslational modification. [PDF]

Basic Clin Pharmacol Toxicol, 2022
Chen X, Yao H, Andrés V, Bergo MO, Kashif M.   +4 more
europepmc   +1 more source

Brief encounters and lasting impressions—How target protein half‐life affects reactive metabolite signaling

The FEBS Journal, EarlyView.
Lipid‐derived reactive electrophile molecules (REMs) are generated from fatty acids through lipoxygenase or cyclooxygenase‐assisted catalysis, or free radical‐induced lipid peroxidation events. REMs so‐produced covalently modify nearby protein‐cysteines, and in the case of ‘first responder’ proteins, can trigger gain‐of‐function signaling with context ...
Marcus J. C. Long, Lorna Birkby, Yimon Aye   +2 more
wiley   +1 more source

Understanding protein ISGylation, a multifaceted posttranslational modification. [PDF]

Cell Chem Biol
Shirley DJ, Yoo E.
europepmc   +1 more source

Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity. [PDF]

Diabetes, 2022
Yang ML, Connolly SE, Gee RJ, Lam TT, Kanyo J, Peng J, Guyer P, Syed F, Tse HM, Clarke SG, Clarke CF, James EA, Speake C, Evans-Molina C, Arvan P, Herold KC, Wen L, Mamula MJ.   +17 more
europepmc   +1 more source

Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community

Haemophilia, EarlyView.
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein, Sterre P. E. Willems, Saskia E. M. Schols, Rosanna Asselta, Gillian Lowe, Neil V. Morgan, Paula D. James   +6 more
wiley   +1 more source

Characterization of posttranslational modification in metabolic dysfunction-associated steatohepatitis: acetylation, lactylation, and phosphorylation. [PDF]

J Lipid Res
Li K, Li Y, Zhang Y, Song S, Pa C, Du C, Yang L, Xue G, Gao H.   +8 more
europepmc   +1 more source

Lactylation may be a Novel Posttranslational Modification in Inflammation in Neonatal Hypoxic-Ischemic Encephalopathy. [PDF]

Front Pharmacol, 2022
Zhou Y, Yang L, Liu X, Wang H.
europepmc   +1 more source

Hb Osler [beta 145(HC2)Tyr-->Asp] results from posttranslational modification.

, 1997
We studied two members of an African American family with erythrocytosis. An abnormal hemoglobin variant with an electrophoretic pattern on cellulose acetate similar to Hb J was identified.
K. Adachi, M. P. Reilly, M. Keller, K. M. Kelly, R. Cubeddu, K. Ohene Frempong, A. C. Kattamis, FORTINA, PAOLO, S. Surrey   +8 more
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