Results 251 to 260 of about 71,707 (290)

Impact of N‐linked glycans on the dual short fibulin/LTBP‐4 axes regulating elastogenesis

The FEBS Journal, EarlyView.
Elastic fiber assembly is orchestrated by multiple glycoproteins. We delineate the molecular basis of two key axes involved in elastic fiber formation—LTBP‐4L/fibulin‐4 and LTBP‐4S/fibulin‐5. We show that N‐linked glycans on these glycoproteins regulate their interactions and conformations, both of which are critical aspects in elastic fiber formation.
Valentin Nelea, Heena Kumra, Chae Syng Lee, Daniel Williamson, Hana Hakami, Rong‐Mo Zhang, Neha E. H. Dinesh, Robert Haltiwanger, Dieter P. Reinhardt   +8 more
wiley   +1 more source

A somatic multiple myeloma mutation unravels a mechanism of oligomerization‐mediated product inhibition in GGPPS

The FEBS Journal, EarlyView.
Geranylgeranyl diphosphate synthase (GGPPS) plays a key role in multiple myeloma biology. Using crystallography, mass spectrometry, and fluorescence spectroscopy, this study shows that a somatic multiple myeloma cell line mutation destabilizes inter‐dimer interactions, resulting in increased GGPPS activity by facilitating product releas.
Ruba Yehia, Jasmína Mária Portašiková, Rut Mor Yosef, Benny Da'adoosh, Alan Kádek, Petr Man, Moshe Giladi, Yoni Haitin   +7 more
wiley   +1 more source

TSC22D1 is a newly identified inhibitor of insulin secretion in pancreatic beta cells

The FEBS Journal, EarlyView.
TSC22D1 acts downstream of glucose signaling and negatively regulates insulin secretion in pancreatic beta cells. Mechanistically, TSC22D1 interacts with FoxO1. Elevated glucose levels enhance the TSC22D1–FoxO1 interaction indirectly by increasing the protein abundance of TSC22D1. Importantly, TSC22D1 and FoxO1 not only physically associate but also co‐
Sümbül Yıldırım, Amit Mhamane, Svenja Lösch, Annika Wieder, Ezgi Ermis, Ann‐Christine König, Sevgican Yilmaz, Stefanie M. Hauck, Fatih Kocabas, Julia Szendroedi, Stephan Herzig, Bilgen Ekim   +11 more
wiley   +1 more source

Posttranslational modifications of phosphodiesterase type 4 enzymes represent novel points for therapeutic targeting

The FEBS Journal, EarlyView.
Enzymes from the phosphodiesterase type 4 family (PDE4) coordinate physiological events driven by the cyclic AMP s(cAMP) signaling pathway by tightly controlling cAMP dynamics in many cell types. Key to this strict regulation is the myriad of posttranslational modifications that alter PDE4 activity, cellular location, and binding partner selection ...
Madihah Hussain, Gonzalo S. Tejeda, George S. Baillie   +2 more
wiley   +1 more source

Competition between binding partners of yeast Pex3 affects peroxisome biology

The FEBS Journal, EarlyView.
Pex3 is a peroxisomal membrane protein (PMP) that specifically recruits several binding partners. In the yeast Hansenula polymorpha, Atg30 (pexophagy), Inp1 (inheritance) and Pex19 (receptor for new PMPs) associate with Pex3. Overexpression of any of these proteins affects peroxisomal processes because these proteins compete for binding to Pex3.
Eline M. F. de Lange, Grzegorz Chojnowski, Jérôme Bürgi, Rifka Vlijm, Matthias Wilmanns, Ida J van der Klei   +5 more
wiley   +1 more source

Structural insights for enhanced ROS detoxification of eKatE, a recently identified catalase in atypical E. coli

The FEBS Journal, EarlyView.
We revealed the crystal structure of eKatE from atypical E. coli. eKatE exhibits a hydrogen‐peroxide‐sensitive major channel, a stabilized dimeric interface, an unusual covalent bond between C392 and Y415, and other distinctive features. These structural features contribute to its enhanced catalase activity compared to KatE in typical E.
Eunhee Koh, Youngki Yoo, Mi Young Yoon, Myung Kyung Choi, Uijin Kim, Jun Bae Park, Sang Sun Yoon, Hyun‐Soo Cho   +7 more
wiley   +1 more source

Structural insights into how vacuolar sorting receptor recognizes the C‐terminal sorting determinant of a vicilin‐like seed storage protein

The FEBS Journal, EarlyView.
Soluble cargo proteins are sorted to the vacuoles via a receptor‐mediated mechanism. Combining crystallographic and mutagenesis studies, we showed how the C‐terminal sorting determinant (ctVSD) of vicilin‐like seed storage protein VL22 is recognized by the protease‐associated domain of Arabidopsis vacuolar‐sorting receptor 1.
Shu Nga Lui, Hsi‐En Tsao, Anthony Hiu‐Fung Lo, Liwen Jiang, Kam‐Bo Wong   +4 more
wiley   +1 more source

Recovery From Anorexia Nervosa: A Concept Analysis

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim Despite decades of research, we still know surprisingly little about how best to bring about lasting recovery from anorexia nervosa (AN). Furthermore, there is a lack of consensus in the research and treatment communities about what constitutes recovery from AN, or whether “recovery” is even an appropriate term to use in this context.
Sarah Ramsay, Kendra Allison
wiley   +1 more source

Clonal longevity and the enigmatic flowering of woody bamboos are associated with rates of protein evolution

Journal of Integrative Plant Biology, EarlyView.
Examining data from 148 Bambusoideae and Pooideae species showed elevated protein evolution rates in highly cloned woody bamboos, providing evidence for an association between protein evolution and life‐history traits in plants with contrasting reproductive modes. ABSTRACT Rates of protein evolution (dN/dS) vary widely across the tree of life.
Xin Wang, Zhi‐Hua Zeng, Peng‐Fei Ma, Yun‐Long Liu, Hua‐Ying Sun, Hong Wang, Hong Ma, De‐Zhu Li, Wei Zhou   +8 more
wiley   +1 more source

Sex‐Related Differences in Histone Acetylation and Tumor Development in a 4‐Nitroquinoline 1‐Oxide and Ethanol‐Induced Oral Squamous Cell Carcinoma Mouse Model

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Oral squamous cell carcinoma (OSCC) is one of the most frequent head and neck cancers. The 4‐nitroquinoline 1‐oxide (4NQO) mouse model of oral carcinogenesis is a well‐established model to investigate the mechanism behind OSCC development, including epigenetic alterations.
Wender Rodrigues Nazário, Anaíra Ribeiro Guedes Fonseca Costa, Débora de Oliveira Santos, Nayara Rúbio Diniz Del Nero, Tamiris Sabrina Rodrigues, Luiza Diniz Ferreira Borges, Carlos Ueira‐Vieira, Sérgio Vitorino Cardoso, Adriano Mota Loyola, Paulo Rogério de Faria   +9 more
wiley   +1 more source