Results 1 to 10 of about 103,127 (237)

CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder

Frontiers in Psychiatry, 2023
IntroductionDNA methylation (DNAm), an epigenetic mechanism, has been associated with opioid use disorder (OUD) in preclinical and human studies. However, most of the studies have focused on DNAm at CpG sites.
Sheila T. Nagamatsu, Sheila T. Nagamatsu, Sheila T. Nagamatsu, Gregory Rompala, Yasmin L. Hurd, Diana L. Núñez-Rios, Diana L. Núñez-Rios, Diana L. Núñez-Rios, Janitza L. Montalvo-Ortiz, Janitza L. Montalvo-Ortiz, Janitza L. Montalvo-Ortiz, Traumatic Stress Brain Research Group, Victor E. Alvarez, David Benedek, Alicia Che, Dianne A. Cruz, David A. Davis, Matthew J. Girgenti, Ellen Hoffman, Paul E. Holtzheimer, Bertrand R. Huber, Alfred Kaye, John H. Krystal, Adam T. Labadorf, Terence M. Keane, Mark W. Logue, Ann McKee, Brian Marx, Deborah Mash, Mark W. Miller, Crystal Noller, JM-O, William K. Scott, Paula Schnurr, Thor Stein, Robert Ursano, Douglas E. Williamson, Erika J. Wolf, Keith A. Young   +38 more
doaj   +1 more source

Neuroticism, Worry, and Cardiometabolic Risk Trajectories: Findings From a 40‐Year Study of Men

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Anxiety is linked to elevated risk of cardiometabolic disease onset, but the underlying mechanisms remain unclear. We examined the prospective association of 2 anxiety facets, neuroticism and worry, with cardiometabolic risk (CMR) trajectories
Lewina O. Lee, Kevin J. Grimm, Avron Spiro, Laura D. Kubzansky   +3 more
doaj   +1 more source

The National Health and Resilience in Veterans Study: A Narrative Review and Future Directions

Frontiers in Psychiatry, 2020
United States (U.S.) veterans are substantially older than their non-veteran counterparts. However, nationally representative, population-based data on the unique health needs of this population are lacking. Such data are critical to informing the design
Brienna M. Fogle, Brienna M. Fogle, Jack Tsai, Jack Tsai, Natalie Mota, Natalie Mota, Ilan Harpaz-Rotem, Ilan Harpaz-Rotem, John H. Krystal, John H. Krystal, Steven M. Southwick, Steven M. Southwick, Robert H. Pietrzak, Robert H. Pietrzak, Robert H. Pietrzak   +14 more
doaj   +1 more source

Examining mGlu5 Receptor Availability as a Predictor of Vulnerability to PTSD: An [F]FPEB and PET Study in Male and Female Rats

Chronic Stress, 2023
Background Females are twice as likely to experience post-traumatic stress disorder (PTSD) than males, yet specific factors contributing to this greater risk are not fully understood.
Ruth H. Asch, Krista Fowles, Robert H. Pietrzak, Jane R. Taylor, Irina Esterlis   +4 more
doaj   +1 more source

The effects of extraversion, social support on the posttraumatic stress disorder and posttraumatic growth of adolescent survivors of the Wenchuan earthquake. [PDF]

PLoS ONE, 2015
The aim of this study was to examine the relationships among extraversion, social support, posttraumatic stress disorder and posttraumatic growth among adolescent survivors of the Wenchuan earthquake.Six hundred thirty-eight participants were selected ...
Xuji Jia, Liuhua Ying, Xiao Zhou, Xinchun Wu, Chongde Lin   +4 more
doaj   +1 more source

How does social support enhance resilience in the trauma-exposed individual?

Ecology and Society, 2015
Although most resilience science has focused on individual-level psychosocial factors that promote individual resilience, theorists and researchers have begun to examine neurobiological and systems-level factors implicated in resilience.
Lauren M. Sippel, Robert H. Pietrzak, Dennis S,. Charney, Linda C. Mayes, Steven M. Southwick   +4 more
doaj   +1 more source

Experimental Combat-Stress Model in Rats: Histological Examination of Effects on Amelogenesis— A Possible Measure of Diminished Vagal Tone Episodes

Dental Anthropology, 2004
Developmental defects of enamel-stress histomarker rings (accentuated striae) may be a potential measure of diminished vagal tone in research on extreme stress such as exposure to combat. To develop an animal model of this measure, we examined the enamel
H. Stefan Bracha, D. Caroline Blanchard, Jeffrey L. Lloyd-Jones, Andrew Williams, Robert J. Blanchard   +4 more
doaj   +1 more source

Place and Posttraumatic Stress Disorder [PDF]

Journal of Traumatic Stress, 2016
AbstractResearch on traumatic stress has focused largely on individual risk factors. A more thorough understanding of risk factors may require investigation of the contribution of neighborhood context, such as the associations between perceived neighbourhood disorder and social cohesion with reported trauma exposure (yes/no) and posttraumatic stress ...
Monson, E, Paquet, C, Daniel, M, Brunet, A, Caron, J   +4 more
openaire   +5 more sources

A longitudinal study of posttraumatic stress disorder symptoms and its relationship with coping skill and locus of control in adolescents after an earthquake in China. [PDF]

PLoS ONE, 2014
BACKGROUND/OBJECTIVES: Post-traumatic stress disorder is a common psychological maladaptation among adolescents after undergoing an earthquake. Knowledge about the prevalence and maintenance of post-traumatic stress disorder symptoms and the changes of ...
Weiqing Zhang, Hui Liu, Xiaolian Jiang, Dongmei Wu, Yali Tian   +4 more
doaj   +1 more source

Posttraumatic Stress Disorder

Continuum, 2015
The objectives of this article are to update the reader on the current definition and diagnostic assessment of posttraumatic stress disorder (PTSD) and to describe its clinical characteristics, discuss its epidemiology and pathophysiologic aspects, as well as to summarize the current therapeutic options for PTSD.The new nomenclature of the Diagnostic ...
G P, Sigurfinnsson, K, Tómasson
openaire   +4 more sources