Results 121 to 130 of about 243,826 (269)

Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS‐Induced Depressive‐Like Behaviors

open access: yesAdvanced Science, EarlyView.
PANEs are specifically designed to enhance the brain delivery efficiency of circDYM compared to commercialized lipid nanoparticles (LNPs). Intranasal administration of PANE‐circDYM effectively alleviated LPS‐induced depressive‐like behaviors by mitigating neuroinflammation and promoting neuroplasticity.
Feng Gao   +11 more
wiley   +1 more source

Enhancing Grasping Function with a Thermoresponsive Ionogel Adhesive Glove for Patients with Rheumatic Diseases

open access: yesAdvanced Science, EarlyView.
This study presents a novel portable grasp‐assist glove, weighing only 47 g. The glove integrates smart adhesive pads and a hands‐free control interface based on IMU, designed to aid rheumatic patients with impaired hand function. The system enables switchable adhesion with independent control and detection of user release intent.
Shiqiang Wang   +11 more
wiley   +1 more source

Vestibular postural control model

open access: yesKybernetik, 1972
Current models for physiological components and a posture control experiment conducted with three normal subjects form the basis for a model which seeks to describe quantitatively the control of body sway when only vestibular motion cues are used. Emphasis is placed on delineating the relative functional roles of the linear and the angular acceleration
openaire   +2 more sources

Bioinspired Mechanisms and Actuation of Soft Robotic Crawlers

open access: yesAdvanced Science, EarlyView.
Researchers have been developing soft materials and robotic crawlers inspired by soft‐bodied animals to mimic effective crawling in complex environments. This review explores the state‐of‐the‐art in soft crawlers, highlighting the interaction between materials, crawling mechanisms, actuation, and applications. The review concludes by providing insights
Min Pan   +6 more
wiley   +1 more source

Accurate and Noninvasive Dysphagia Assessment via a Soft High‐Density sEMG Electrode Array Conformal to the Submental and Infrahyoid Muscles

open access: yesAdvanced Science, EarlyView.
A stretchable, breathable, large‐area high‐density sEMG (HD‐sEMG) electrode array is reported, which enables seamless integration to the complex surface of the submental and infrahyoid muscles to detect high‐fidelity HD‐sEMG signals during swallowing.
Weijie Hong   +9 more
wiley   +1 more source

Utilizing Caenorhabditis Elegans as a Rapid and Precise Model for Assessing Amphetamine‐Type Stimulants: A Novel Approach to Evaluating New Psychoactive Substances Activity and Mechanisms

open access: yesAdvanced Science, EarlyView.
This study uses Caenorhabditis elegans to assess the activity of amphetamine‐type stimulants (ATS) and their analogs. The research highlights the roles of dopamine and serotonin pathways, distinguishes chiral forms of ATS, and identifies structure‐activity relationships. These findings provide a rapid and cost‐effective model for evaluating the effects
Yuanpeng Li   +3 more
wiley   +1 more source

Rational Design and Organoid‐Based Evaluation of a Cocktail CAR‐γδ T Cell Therapy for Heterogeneous Glioblastoma

open access: yesAdvanced Science, EarlyView.
A novel “prof” cocktail therapy is designed. It screens antigens, selects personalized antigen panels, engineers optimized CAR‐Vδ1 T cells, and tests in patient‐derived GBM organoids, offering hope for effective CAR‐T drugs against heterogeneous solid tumors. Abstract Various challenges, including tumor heterogeneity and inadequate T cell infiltration,
Guidong Zhu   +12 more
wiley   +1 more source

Early detection of risk of reading difficulties using a working memory assessment battery

open access: yesBritish Educational Research Journal, Volume 48, Issue 6, Page 1183-1197, December 2022., 2022
Abstract Research suggests a role for aspects of the working memory system in reading. While much of the evidence points to a role for working memory capacity and the phonological loop, more recent work indicates a role for the central executive component, although findings remain unclear.
Susan J. Atkinson, Colin R. Martin
wiley   +1 more source

Functional Divergence of Plant‐Derived Thaumatin‐Like Protein Genes in Two Closely Related Whitefly Species

open access: yesAdvanced Science, EarlyView.
Two closely related whitefly species, Trialeurodes vaporariorum and Bemisia tabaci, are found to each possess a plant‐derived TLP gene, but with entirely different functions. This finding of functional divergence challenges the notion that HGT genes maintain similar functions across species and shows that they can follow unique evolutionary paths that ...
Yuan Hu   +12 more
wiley   +1 more source

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