Results 161 to 170 of about 239,204 (360)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

open access: yesAdvanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao   +4 more
wiley   +1 more source

Postural control mechanisms

open access: yes, 2020
„Stehen“, die Fähigkeit des Menschen in eine aufrechte Standposition zu gehen, scheint eine grundlegende menschliche Fähigkeit zu sein und ist im täglichen Leben allgegenwärtig. Aus Sicht der Sportwissenschaft ist „der Stand“ jedoch eine komplexe Aufgabe, die immer noch Fragen zu den zugrunde liegenden Steuerungsmechanismen aufwirft.
openaire   +1 more source

A Review on Biodegradable Materials of Sustainable Soft Robotics and Electronics

open access: yesAdvanced Science, EarlyView.
Biodegradable materials are gaining increasing attention in soft robotics and electronics due to their environmental friendliness, showing great potential for sustainability. In this review, the classification of biodegradable materials, their applications in the field of soft robotics and electronics, as well as the challenges and future prospects ...
Yizhu Xie   +8 more
wiley   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

open access: yesAdvanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen   +8 more
wiley   +1 more source

Effects of Plantar Flexor Muscles Fatigue on Postural Control during Quiet Stance and External Perturbation in Healthy Subjects

open access: yesJournal of Biomedical Physics and Engineering, 2019
Background: The maintenance of postural control is a key component in dynamic physical activity, especially during muscle fatigue and against external forces.
Rojhani-Shirazi Z.   +2 more
doaj  

Dynamical patterns of human postural responses to emotional stimuli [PDF]

open access: yes, 2011
Erotic scenes and images of mutilated bodies are emotional stimuli that have repeatedly shown to evoke specific neurophysiological responses associated with enhanced attention and perceptual processing.
Jaime Vila   +3 more
core   +1 more source

Effects of resistance training on postural control in Parkinson’s disease: a randomized controlled trial [PDF]

open access: gold, 2021
Janini Chen   +7 more
openalex   +1 more source

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