Results 21 to 30 of about 1,274,811 (203)

Molecular Surveillance and Evolutionary Dynamics of Porcine Circovirus Types 2 and 3 in China, 2022-2025. [PDF]

Transbound Emerg Dis
Porcine circovirus types 2 (PCV2) and 3 (PCV3) are globally distributed pathogens associated with reproductive disorders, subclinical infections, and multifactorial disease complexes in swine. To elucidate their epidemiological and evolutionary patterns in China, we examined 8426 clinical samples collected from 28 provincial‐level regions between 2022 ...
Chen Y, Lu Y, Zeng Y, Hu Y, Dong L, Lei M, Li P, Yan W, Jongkaewwattana A, Li W, Yu X, He Q.   +11 more
europepmc   +2 more sources

Overexpression of programmed death ligands in naturally occurring postweaning multisystemic wasting syndrome. [PDF]

Viral Immunol, 2015
Postweaning multisystemic wasting syndrome (PMWS) is regarded as an immunosuppressive disease in pigs caused by porcine circovirus type 2 (PCV2). Immune inhibitory receptors, particularly programmed death 1/programmed death-ligands (PD-1/PD-Ls) are presumably involved in the immunopathogenesis of PMWS.
Yue F, Cheng A, Zhu Y, Li P, Zhang Y, Sun G, Wang M, Wang X.   +7 more
europepmc   +4 more sources

Emergence of a Novel CRESS-DNA Virus Associated with Swine Reproductive Failure in China. [PDF]

Transbound Emerg Dis
The continuous emergence of circular Rep‐encoding single‐stranded (CRESS) DNA viruses across diverse hosts has been closely associated with the occurrence of severe diseases. Four circoviruses within the genus Circovirus have been identified in pigs, including porcine circovirus Type 1 (PCV1), PCV2, PCV3, PCV4, and PCV5.
Liu X, Li Y, Xiao J, Zhang X, Liu Y, Li Z, Wang L, Zhang L, Liu Y, Liang P, Xu Z, Liu Y, Song C.   +12 more
europepmc   +2 more sources

Experimental Inoculation of Porcine Circovirus 3 (PCV‐3) in Pregnant Gilts Causes PCV‐3‐Associated Lesions in Newborn Piglets that Persist until Weaning

Transboundary and Emerging Diseases, Volume 2023, Issue 1, 2023., 2023
Porcine circovirus 3 (PCV‐3) has been detected in cases of reproductive failure but the pathogenesis of such infection is poorly understood. So far, experimental PCV‐3 inoculations have been performed only in piglets. Therefore, through the experimental inoculation of pregnant gilts at two different time points (second and last third of gestation ...
Àlex Cobos, Albert Ruiz, Mónica Pérez, Anna Llorens, Eva Huerta, Florencia Correa-Fiz, Robert Lohse, Mònica Balasch, Joaquim Segalés, Marina Sibila, Makoto Ozawa   +10 more
wiley   +1 more source

Investigating the Genetic Evolution of PCV2 and PCV3 across Six Swine Herds in China from 2020 to 2021

Transboundary and Emerging Diseases, Volume 2023, Issue 1, 2023., 2023
To elucidate the prevalence, molecular evolution, and coinfection of PCV2 and PCV3 in China, we collected samples from six large‐scale swine herds located in Heilongjiang, Henan, Hebei, and Hubei provinces and Xinjiang Uygur autonomous region from 2020 to 2021. Overall, 1,201 samples were analyzed and sequenced by PCR to identify the dominant genotypes
Chenchen Cui, Menghang Wang, Qianru Zhang, Shujie Wang, Hongliang Zhang, Zhijun Tian, Tongqing An, Xuehui Cai, Gang Wang, Subodh Samrat   +9 more
wiley   +1 more source

Transcriptomic and Proteomic Approaches Reveal the Biological Functions of Two Novel Porcine‐Origin Noncoding DNA Molecules

Transboundary and Emerging Diseases, Volume 2023, Issue 1, 2023., 2023
Porcine circovirus‐like mini agents (PCVLs) with small circular noncoding DNA genomes have recently been discovered in animals. Currently, the biological activity of PCVLs remains unclear. In this study, we conducted transcriptomic and proteomic analyses to compare the differential expression of genes and proteins in the livers of PCVL258/PCVL264 ...
Libin Wen, Jianping Xie, Qi Xiao, Kongwang He, Chunfu Zheng   +4 more
wiley   +1 more source

Porcine Circovirus Type 3: Diagnostics, Genotyping, and Challenges in Vaccine Development

Transboundary and Emerging Diseases, Volume 2023, Issue 1, 2023., 2023
Porcine circovirus (PCV) comprises four distinct species, namely, PCV1–4, with considerable differences between them, resulting in limited crossprotection. PCV2 inflicts substantial economic losses on the swine industry. PCV3 was found to have been circulating before its discovery in 2015.
Stella Pranoto, Hsing-Chieh Wu, Chun-Yen Chu, Lin-Zhu Ren   +3 more
wiley   +1 more source

Regional Cross‐Sectional Based Study and Associated Risk Factors of Porcine Circovirus 2 in Nigerian Pigs

Transboundary and Emerging Diseases, Volume 2023, Issue 1, 2023., 2023
Porcine circovirus 2 (PCV2) is a swine viral pathogen of substantial economic importance in pig farming globally. However, large‐scale surveillance is needed to determine its prevalence and associated risk factors in the Nigerian pigs. We conducted molecular‐based surveillance and mapping of PCV2 in southwest Nigeria to assess its prevalence and ...
Kayode O. Afolabi, Olufemi S. Amoo, Tochukwu I. Onuigbo, Joy I. Oraegbu, Ayomikun A. Awoseyi, Folorunso O. Fasina, Oluwawemimo O. Adebowale, Fedor Korennoy   +7 more
wiley   +1 more source

Application of shotgun metagenomics sequencing and targeted sequence capture to detect circulating porcine viruses in the Dutch–German border region

Transboundary and Emerging Diseases, Volume 69, Issue 4, Page 2306-2319, July 2022., 2022
Abstract Porcine viruses have been emerging in recent decades, threatening animal and human health, as well as economic stability for pig farmers worldwide. Next‐generation sequencing (NGS) can detect and characterize known and unknown viruses but has limited sensitivity when an unbiased approach, such as shotgun metagenomics sequencing, is used.
Leonard Schuele, Erley Lizarazo‐Forero, Katrin Strutzberg‐Minder, Sabine Schütze, Sandra Löbert, Claudia Lambrecht, Jürgen Harlizius, Alex W. Friedrich, Silke Peter, John W. A. Rossen, Natacha Couto   +10 more
wiley   +1 more source

Multisystemic lymphoplasmacytic inflammation associated with PCV‐3 in wasting pigs

Transboundary and Emerging Diseases, Volume 68, Issue 6, Page 2969-2974, November 2021., 2021
Abstract Porcine circovirus 3 (PCV‐3) has been detected in diseased and healthy pigs of different ages. Several reports have associated the agent with reproductive failure and mummified and stillborn piglets. One report from North America has proposed a consistent potential association with postweaning disorders.
Jaume Alomar, Viviane Saporiti, Mònica Pérez, Diogo Gonçalvez, Marina Sibila, Joaquim Segalés   +5 more
wiley   +1 more source