Results 131 to 140 of about 379,942 (267)

Optimization Leading to a Potent and Selective Cbl‑b Inactive-State Inhibitor That Demonstrated <i>In Vivo</i> Efficacy. [PDF]

ACS Med Chem Lett
Liang J, Lambrecht MJ, Huestis MP, Zhu B, Barton LM, Castanedo GM, Ung PM, Larouche-Gauthier R, Jakalian A, Leclerc JP, Yadav A, Haghshenas P, Aubert-Nicol S, Ismaili H, Zhao L, Leblanc M, de Almeida H, Wang Q, Garner T, Tan S, Prangley MS, Pang J, Murray JM, Yu C, Hsu PL, Rutz S, Ishizuka I, Huang H, Gao C, Chen M, Mutter-Rottmayer L, Kakiuchi-Kiyota S, Leung DH, Kou P, Bao L, Wang X.   +35 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Optimization and <i>In Vivo</i> Characterization of a Series of Cbl‑b Inactive-State Inhibitors. [PDF]

ACS Med Chem Lett
Lambrecht MJ, Liang J, Ung PM, Huestis MP, Zhu BY, Barton LM, Castanedo GM, Zbieg JR, Larouche-Gauthier R, Jakalian A, Leclerc JP, Yadav A, Haghshenas P, Aubert-Nicol S, Ismaili H, Zhao L, Leblanc M, Wang J, Wang S, Wang Q, Garner T, Tan S, Prangley M, Broccatelli F, Pang J, Murray J, Yu C, Hsu P, Rutz S, Kakiuchi-Kiyota S, Ishizuka I, Leung DH, Kou P, Bao L, Wang X.   +34 more
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Establishment and Validation of a Cell-Based Relative Potency Method for Respiratory Syncytial Virus mRNA Vaccine Drug Substance. [PDF]

Vaccines (Basel)
Zheng S, Zhang X, Li W, Zhao H.
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Lipidated peptides and the limits of chemical control. [PDF]

Front Chem
Roque-Borda CA, Sharma A, Pavan FR, de la Torre BG, Albericio F.   +4 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Novel Competitive, Nonpeptidic, SARS-CoV‑2 M^pro Inhibitors with Improved Solubility. [PDF]

ACS Med Chem Lett
Sahin Z, Rivera M, Yang Y, Liu K, Sahin GPC, Bacsa J, Pelly SC, Liotta DC.   +7 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source