Results 141 to 150 of about 514,099 (251)

Substrate morphology modulates bacteriophage mobility and alters bactericidal potency. [PDF]

PLoS One
Wang H, Awolusi OO, Jaganathan SK, Lyu J, Liu C, Tucker N, Onarinde BA.   +6 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Measurement of Anesthetic Potency

, 1966
In "Temperature dependence of anesthesia in goldfish" (l), Cherkin and Catchpool introduce a technique for making quantitative measurements of the anesthetic potency of water-soluble agents.
Fenichel, I. Robert, Cherkin, Arthur, Horowitz, Samuel B., Catchpool, J. F.   +3 more
core  

Nitrile-Based Inhibitors Targeting both SARS-CoV‑2 Main Protease and Human Cathepsin L. [PDF]

ACS Med Chem Lett
Barasa L, Chen Y, Shaqra AM, Adnan SFZ, Intravaia LE, Huchaiah S, Allabaji A, S KK, Vidadala SR, Patil SN, Hale J, Schiffer CA, Fitzgerald KA, Thompson PR.   +13 more
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Detection and Potency Classification of Pre- and Pro-Haptens Using the SENS-IS Assay: The Role of Metabolically Competent Reconstructed Skin. [PDF]

Toxics
Cottrez F, Boitel E, Sahli E, Bastard M, Capallere C, Groux H.   +5 more
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Pt(iv) scaffold effects on nucleolar stress and DNA damage response pathways. [PDF]

RSC Chem Biol
Griffin CR, DeRose VJ.
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Glucocorticoids: an enemy or a friend for the dermatologist? recommendations for proper use and safe discontinuation. [PDF]

Endocrine
Sali E, Paschou IA, Dimopoulou SM, Tagka A, Chasapi V, Nicolaidou E, Stratigos AJ, Peppa M, Paschou SA.   +8 more
europepmc   +1 more source