Results 161 to 170 of about 783,846 (314)

A Metabolism-Informed Neural Network Identifies Pathways Influencing the Potency and Toxicity of Antimicrobial Combinations. [PDF]

NPJ Drug Discov
Arora HS, Lev K, Robida A, Velmurugan R, Chandrasekaran S.   +4 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Normalizing Covalent Potency for Electrophilicity with Ligand Reactivity Efficiency. [PDF]

J Med Chem
Horning BD, Kingston C, Simon GM, Patricelli MP, Weinstein DS, Cook BN.   +5 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Analysis of Regulatory Inhalation Unit Risk Estimates for Cobalt: Comparison to Epidemiological Data. [PDF]

Risk Anal
Marshall LP, Viegas V, Maier A, Marsh G, Kreider ML.   +4 more
europepmc   +1 more source

The antiscorbutic potency of apples [PDF]

Biochemical Journal, 1930
M F, Bracewell, E, Hoyle, S S, Zilva
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Potency-related effects of smoked cannabis on simulated driving performance: a randomized, controlled crossover trial. [PDF]

Sci Rep
Brands B, Zaweel A, Wright M, Di Ciano P, Wickens CM, Matheson J, Fares A, Hasan OSM, Sanches M, Sproule B, Huestis MA, Brown TL, Le Foll B.   +12 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Integrated Assessment of Neurobehavioral and Cardiotoxic Effects of Pyrrolidine-Containing Cathinones in Zebrafish: Structural Determinants of Functional Safety Profiles. [PDF]

Int J Mol Sci
Aljabasini O, Tagkalidou N, Pazos MD, García-Díez G, Prats E, Seco R, Berzosa X, López-Arnau R, Raldua D.   +8 more
europepmc   +1 more source