Results 191 to 200 of about 583,846 (360)

Supplementary Figure 5 from AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer

, 2023
Michael J. Giffin, Keegan S. Cooke, Edward K. Lobenhofer, Juan Estrada, Jinghui Zhan, Petra Deegen, Melissa Thomas, Christopher M. Murawsky, Jonathan Werner, Siyuan Liu, Fei Lee, Oliver Homann, Matthias G. Friedrich, Joshua T. Pearson, Tobias Raum, Yajing Yang, Sean Caenepeel, Jennitte Stevens, Pedro J. Beltran, Jude Canon, Angela Coxon, Julie M. Bailis, Paul E. Hughes   +22 more
openalex   +1 more source

Proportion of patients in south London with first-episode psychosis attributable to use of high potency cannabis: a case-control study.

Lancet psychiatry, 2015
M. di Forti, A. Marconi, E. Carra, S. Fraietta, A. Trotta, Matteo Bonomo, Francesca Bianconi, Poonam Gardner-Sood, J. O'Connor, M. Russo, S. Stilo, T. Marques, V. Mondelli, P. Dazzan, C. Pariante, A. David, F. Gaughran, Z. Atakan, C. Iyegbe, J. Powell, C. Morgan, M. Lynskey, R. Murray   +22 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Improved reconstruction of single-cell developmental potential with CytoTRACE 2. [PDF]

Nat Methods
Kang M, Gulati GS, Brown EL, Qi Z, Avagyan S, Armenteros JJA, Gleyzer R, Zhang W, Steen CB, D'Silva JP, Schwab J, Clarke MF, Chaudhuri AA, Newman AM.   +13 more
europepmc   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

High-potency multi-strain probiotic formulations for safety and improvement of gastrointestinal function and intestinal health: a randomized controlled clinical trial. [PDF]

Front Nutr
Zhang X, Wu Y, Jiang Y, Fan J, Dong Y, Fang S, Zhu J, Gu S.   +7 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Nanobody-drug conjugates for targeting specific GPCR pairs. [PDF]

PLoS Biol
Huang X, Roth BL.
europepmc   +1 more source

Comparison of nonhuman primate antibodies against Haemophilus influenzae type b polysaccharide with human antibodies in oligoclonality and in vivo protective potency [PDF]

, 1994
K H Kim, M K Park, C C Peeters, Jan Poolman, Michael H. Shearer, R C Kennedy, Moon H. Nahm   +6 more
openalex   +1 more source

Temperature and drug potency [PDF]

Anaesthesia, 1991
openaire   +2 more sources