Results 321 to 330 of about 1,009,444 (403)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Engineering multispecific antibodies with complete killing selectivity through the closed-loop integration of machine learning and high-throughput experimentation. [PDF]

MAbs
Grace J, Colin PY, Foxler D, Haynes W, Howsham C, Kassimatis L, Mavrogonatou L, Mighell R, McClory J, Mullin M, Ogola T, Townsend A, Ravi S, Wossnig L, van Heeke G.   +14 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Structural insights into the development of inhibitors for inositol phosphate kinases. [PDF]

FEBS Lett
Wang H.
europepmc   +1 more source

Comparison of Ultrapreservation and Retzius-Sparing Techniques in Robotic Radical Prostatectomy: Single-Center Experience. [PDF]

Medicina (Kaunas)
Beyatlı M, Güngör HS, Haberal HB, İnkaya A, Sobay R, Tahra A, Küçük EV.   +6 more
europepmc   +1 more source

Exploratory evidence of mitigated immune imprinting following concomitant COVID-19 and influenza vaccination. [PDF]

NPJ Vaccines
Choi MJ, Gwak W, Yun JY, Ju HJ, Choi E, Cheong HJ, Kim WJ, Kim C, Kim HJ, Jang AY, Yoon S, Lee JW, Jeong HS, Song JY.   +13 more
europepmc   +1 more source

Exploiting intracellular oncogenic proteins to release cytotoxins. [PDF]

RSC Med Chem
Schild M, Gillingham D.
europepmc   +1 more source

Anticholinergics, executive function, and cognitive/behavioral changes in Down syndrome. [PDF]

Alzheimers Dement
Lee NR, McQuaid GA, Jiddou H, McNulty J, Grosman HE, Tucker KT, O'Brien M, Wallace GL.   +7 more
europepmc   +1 more source

Morpholino-RNA duplex exhibits robust, sustained, and safe steric-block antisense activity by intracerebroventricular and intrathecal injection. [PDF]

Nat Commun
Yanagidaira M, Nagata T, Hasegawa J, Ishii T, Ebihara S, Nawa M, Yokota T.   +6 more
europepmc   +1 more source

Comparison between Two In Vitro ELISA-Based Assays in the Determination of Antivenom Potency

, 2009
Nihal M. Ibrahim, N. M. Farid
openalex   +1 more source