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Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency

open access: yesAdvanced Materials, 2023
The transfection potency of lipid nanoparticle (LNP) mRNA systems is critically dependent on the ionizable cationic lipid component. LNP mRNA systems composed of optimized ionizable lipids often display distinctive mRNA‐rich “bleb” structures.
Pieter Cullis
exaly   +2 more sources
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Exploring Potency

Proceedings of the 21th ACM/IEEE International Conference on Model Driven Engineering Languages and Systems, 2018
The original notion of potency -- one of the core features underpinning many forms of multi-level modeling -- has come under pressure in several ways: First, since its inception new modeling challenges have come to the fore that raise serious questions about classic potency.
Thomas Kühne
openaire   +2 more sources

Single-cell entropy for accurate estimation of differentiation potency from a cell’s transcriptome

open access: yesNature Communications, 2017
The ability to quantify differentiation potential of single cells is a task of critical importance. Here we demonstrate, using over 7,000 single-cell RNA-Seq profiles, that differentiation potency of a single cell can be approximated by computing the ...
Andrew E Teschendorff
exaly   +2 more sources

Risk Assessment of Per‐ and Polyfluoroalkyl Substance Mixtures: A Relative Potency Factor Approach

Environmental Toxicology and Chemistry, 2020
Per‐ and polyfluoroalkyl substances (PFAS) often occur together as contamination in exposure media such as drinking water or food. The relative potency factor (RPF) methodology facilitates the risk assessment of mixture exposure.
W. Bil   +5 more
semanticscholar   +1 more source

Potency and Prostatectomy

British Journal of Urology, 1977
A prospective questionnaire study with a 6-month follow-up was carried out to determine the incidence of post-prostatectomy impotence. 57% of patients were potent at the time of operation. A man with full potency had a 4% chance of becoming totally impotent and a 3% chance of becoming partially impotent. A man with failing preoperative potency had a 10%
T B, Hargreave, T P, Stephenson
openaire   +2 more sources

Periodontal Ligament Stem Cells: Regenerative Potency in Periodontium

Stem Cells and Development, 2019
Periodontium is consisted of root cementum, bone lining the tooth socket, gingiva facing the tooth, and periodontal ligament (PDL). Its primary functions are support of the tooth and protection of tooth, nerve, and blood vessels from injury by mechanical
Atsushi Tomokiyo, Naohisa Wada, H. Maeda
semanticscholar   +1 more source

Ranking of carcinogenic potency using a relative potency approach

Archives of Environmental Contamination and Toxicology, 1991
Protocols for long-term carcinogen bioassays have become highly refined. The ability to interpret these bioassay results beyond the experimental setting, however, has not improved commensurately. As a consequence, society is still faced with the fact that data derived in these bioassays reflect highly specific experimental conditions which are vastly ...
L R, Glass   +3 more
openaire   +2 more sources

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