Results 51 to 60 of about 997,205 (406)

Certification of a pharmacopoeial reference standard for potency testing of recombinant interferon α-2b

Биопрепараты: Профилактика, диагностика, лечение
SCIENTIFIC RELEVANCE. Potency testing of recombinant interferons requires a reference standard. The availability of International Standards (ISs) that are commonly used to assess the quality of recombinant interferons is currently limited. Therefore, the
L. A. Gaiderova, Yu. N. Lebedeva, T. N. Lobanova, E. K. Lipatova, R. A. Volkova, O. V. Fadeikina   +5 more
doaj   +1 more source

The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma. [PDF]

, 2014
Blocking the bioactivity of allergens is conceptually attractive as a small-molecule therapy for allergic diseases but has not been attempted previously.
Anandan C., Arbes S. J., Asokananthan N., Billson J., Boyd M. J., Brown A., Brown A. D., Chan W. C., Chen J. C., Clive Robinson, Comoy E. E., David R. Garrod, Fattouh R., Gary K. Newton, Gelber L. E., Gough L., Jahnsen F. L., Jie Chen, Jihui Zhang, Jonathan P. Richardson, Kerry Jenkins, King C., Liu H., Marcaccini S., Mark R. Stewart, Meriel R. Major, Milan D. S., Moffatt M. F., Möller G. M., Nicola J. Francis-Newton, Peat J. K., Peat J. K., Pei Lai, Pichavant M., Platts-Mills T. A., Platts-Mills T. A., Platts-Mills T. A. E., Platts-Mills T. A. E., Prefontaine D., Purello-D’Ambrosia F., Rebekah E. Key, Robinson C., Silvestri M., Smith J. M., Sporik R., Squillace S. P., Steven M. Lloyd, Stewart G. A., Stuart Firth-Clark, Takai T., Trevor R. Perrior, Wan H., Ying S., Zhang J., Zhang J., Zhang J., Zhang J.   +56 more
core   +2 more sources

Increasing potency and price of cannabis in Europe, 2006–16

Addiction, 2019
Aims To quantify changes in (i) potency (concentration of Δ9‐tetrahydrocannabinol; %THC), (ii) price (euros/g of cannabis) and (iii) value (mg THC/euro) of cannabis resin and herbal cannabis in Europe. Design Repeated cross‐sectional study.
T. Freeman, Teodora Groshkova, A. Cunningham, R. Sedefov, P. Griffiths, M. Lynskey   +5 more
semanticscholar   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Biomarker Signatures of Quality for Engineering Nasal Chondrocyte-Derived Cartilage

Frontiers in Bioengineering and Biotechnology, 2020
The definition of quality controls for cell therapy and engineered product manufacturing processes is critical for safe, effective, and standardized clinical implementation.
M. Adelaide Asnaghi, Laura Power, Andrea Barbero, Martin Haug, Ruth Köppl, David Wendt, Ivan Martin, Ivan Martin   +7 more
doaj   +1 more source

Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency

PLoS ONE, 2019
Doxorubicin is a chemotherapeutic agent that is commonly used to treat a broad range of cancers. However, significant cardiotoxicity, associated with prolonged exposure to doxorubicin, limits its continued therapeutic use.
Christina E. M. Schindler, Andie Collinson, Carl Matthews, A. Pointon, Lesley Jenkinson, R. Minter, T. Vaughan, N. Tigue   +7 more
semanticscholar   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Epitope Profiling of SARS-CoV-2 Spike Antigen Provides a Novel Strategy for Developing ELISAs Specific for Different Spike Protein Variants in Bivalent Vaccine Formulations

Vaccines
Background/Objectives: An initial COVID-19 candidate vaccine containing a purified ancestral SARS-CoV-2 spike antigen was characterized with an ELISA using recombinant monoclonal antibodies (mAbs) generated against this variant.
Luciano Ettorre, Trevor Williams, Camille Houy, Shaolong Zhu, Michael Kishko, Ali Azizi, Andrew D. James, Beata Gajewska, Jason Szeto   +8 more
doaj   +1 more source

Ius sive potentia: Paul and Spinoza [PDF]

Filozofija i Društvo, 2020
This article is a part of a research project entitled Law as Potency, that, broadly put, investigates the relation between law and ontology. I argue, starting from St. Paul, that an ontological perspective can be understood as the possibility of
Milović Miroslav
doaj   +1 more source

STUDI POTENSI TOLERANSI ISOLAT FUNGI LIMBAH COMBERAN \ud TERHADAP DETERGEN, SABUN MANDI DAN SABUN COLEK KAWASAN \ud PADAT HUNI DI KOTA MALANG [PDF]

, 2008
Detergent and Soap is cleanser of sintetic having negative impact to health either through is direct (physical contact) and also indirectly (residing in nature or environment in the form of waste).
Su’udiyah, Sulfi
core