Results 251 to 260 of about 7,504,315 (296)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
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Study on nutritional status and incidence of sarcopenia in elderly patients with chronic heart failure. [PDF]
Asia Pac J Clin NutrSong S, Du H, Lu X, Luo B, Li Z.
europepmc +1 more source
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Assessment of the genotoxic potential of mintlactone
Food and Chemical Toxicology, 2022Mintlactone (chemical name 3,6-dimethyl-5,6,7,7a-tetrahydro-1-benzofuran-2(4H)-one, CAS Number 13341-72-5) is a fragrance and flavor ingredient with reported uses in many different cosmetics, personal care, and household products. In order to evaluate the genotoxic potential of mintlactone, in vitro and in vivo genotoxicity tests were conducted ...
Yax Thakkar +7 more
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Assessment of abuse potential of carfentanil
Addiction Biology, 2023AbstractCarfentanil, as a fentanyl analogue, is a potent synthetic opioid. It has been controlled in many countries, and its emergence has been highlighted by many recent reports. However, although discriminative stimulus effects of carfentanil in rats had been reported, its abuse potential has not been fully evaluated.
Jiayun, Wei +8 more
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Assessment of the allergenic potential of proteins
Toxicology Letters, 2003The development of novel foods, including foods derived from genetically modified plants, has generated considerable interest in the design and application of appropriate safety assurance measures. A specific focus of attention has been on allergenicity, and in particular the need to determine whether the products of novel genes introduced into food ...
Kimber, Ian +2 more
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Assessment of mutagenic potential of thiram
Food and Chemical Toxicology, 1997Thiram is a widely used dithiocarbamate fungicide. In this study, the mutagenicity of thiram was investigated using the micronucleus and dominant lethal tests in Swiss albino mice. A single ip injection of 100 mg thiram/kg body weight, which is the maximum tolerated dose (MTD), significantly induced micronucleus formation in bone marrow cells after 30 ...
R C, Agrawal, Y, Shukla, N K, Mehrotra
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Assessment of the Malignant Potential of Cystoplasty
British Journal of Urology, 1989Summary— The study group comprised 34 patients with either an ileal augmentation cystoplasty or a colonic substitution cystoplasty. The histological appearance of the intestinal segment, suture line, bladder remnant and bacterial colonisation of the urine and urinary nitrosamine levels were recorded.
D E, Nurse, A R, Mundy
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Microfluidic assessment of metastatic potential
Nature Biomedical Engineering, 2019A microfluidic assay that quantifies the abundance and degree of proliferation of migratory cells predicts the metastatic potential of breast-cancer cell lines and patient-derived cells.
Zhengpeng Wan, Roger D. Kamm
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Assessment of Rehabilitation Potential
Clinics in Geriatric Medicine, 1993Physicians often have a powerful influence on patients and their families. If we enthusiastically recommend a realistic rehabilitation program, it will help our patients face the arduous process of functional recovery. Rehabilitation potential depends on many factors.
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