Results 91 to 100 of about 4,289,395 (298)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Calculation of horizontal displacement of loess fill slope supported by frame prestressed anchors based on minimum potential energy method. [PDF]
Sci Rep, 2022 Zhao Z, Zhu Y, Ye S.
europepmc +1 more source
Ab-initio calculation of the ${}^6Li$ binding energy with the Hybrid Multideterminant scheme
, 2010 We perform an ab-initio calculation for the binding energy of ${}^6Li$ using the CD-Bonn 2000 NN potential renormalized with the Lee-Suzuki method. The many-body approach to the problem is the Hybrid Multideterminant method.
A.F. Lisetskiy +33 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2018 This paper proposes a new mechanism and a modeling method for continuum manipulators. The new mechanism is an anti-twist mechanism. Continuum manipulators have the merit of flexibility. However flexibility causes unexpected motions such as twisting under
Takaaki TOKUNAGA +2 more
doaj +1 more source
N-dimensional electron in a spherical potential: the large-N limit
, 2006 We show that the energy levels predicted by a 1/N-expansion method for an N-dimensional Hydrogen atom in a spherical potential are always lower than the exact energy levels but monotonically converge towards their exact eigenstates for higher ordered ...
't Hooft +22 more
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
An innovative deformation coordination method for analyzing distortion effects on box girders
Scientific ReportsA deformation coordination method is proposed in this study to account for the distortion effects on a box girder. The differential equation for distortion in vertical web box girders is derived based on the deformation coordination condition of the ...
Chenguang Wang +7 more
doaj +1 more source
Determination of the chemical potential using energy-biased sampling
, 2005 An energy-biased method to evaluate ensemble averages requiring test-particle insertion is presented. The method is based on biasing the sampling within the subdomains of the test-particle configurational space with energies smaller than a given value ...
Allen M. +4 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source