Results 131 to 140 of about 1,340,613 (267)

An overview of the research on the correlation between solar energy utilization potential and spatial morphology

Results in Engineering
The combination of solar energy utilization and spatial morphology is crucial to improve urban energy efficiency. This paper explores the internal relationship between solar energy potential assessment and spatial form indicators from three aspects ...
Dexin Li, Xiurong Cui, Ligang Shi, Yuan Li   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Application of equivalent occupation method as a tool for energy management in hotel sector [PDF]

, 2018
At nowadays, the operational control of energy performance indicators based on the equivalent occupation method plays a fundamental role in the rational use of energy for the hotel sector, since it allows in a competitive way to comply with the quality ...
Lourdes Meriño, Cardenas Escorcia, Yulineth del Carmen, Valencia Ochoa, Guillermo Eliecer, Guillermo Valencia Ochoa, Meriño, Lourdes, Yulineth Cardenas   +5 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Emergy-based energy return on investment method for evaluating energy exploitation

, 2017
To consider the environmental impacts of energy resource exploitation and better estimate the energy return of investment (EROI), this paper establishes a new emergy-based method (EmEROI) that can capture the essence of energy resource exploitation.
Yingchao Chen, Lianyong Feng, Mikael Höök, Wang, Jianliang,, Höök, Mikael,, Jianliang Wang, Chen, Yingchao,, Feng, Lianyong,   +7 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

ASSESSMENT OF GEOTHERMAL POTENTIAL IN KEPAHIANG DISTRICT USING THE MAGNETOTELLURIC METHOD FOR RENEWABLE ENERGY DEVELOPMENT

Rudarsko-geološko-naftni Zbornik
Indonesia, located on the Pacific Ring of Fire, has 147 volcanoes, with 76 still active, creating optimal conditions for geothermal energy development. Kepahiang Regency in Bengkulu Province is particularly promising for geothermal exploration, evidenced
Muchammad Farid, Hery Suhartoyo, Arif Ismul Hadi, Refrizon Refrizon, Andre Rahmat Al-Ansory, Hana Raihana   +5 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source