Results 121 to 130 of about 1,340,613 (267)

Study of five-dimensional potential-energy surfaces for actinide isotopes by the macroscopic-microscopic method

open access: yesEPJ Web of Conferences, 2017
In this work, the nuclear potential-energy of the deformed nuclei as a function of shape coordinates is calculated in a five-dimensional (5D) parameter space of the axially symmetric generalized Lawrence shapes, on the basis of the macroscopic ...
Fan T.S.   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The use of willingness-to-pay (WTP) method to identify potential for use of solar energy [PDF]

open access: yes, 2008
Solar energy is one of the renewable energy systems that are the most environmentally friendly means of providing electricity. Developing countries such as in Asia has experiencing spectacular economic growth over the past two decades.
Abdol Mulok, Norleen Fariza
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Using Weibull Distribution In Wind Energy Potential And Economic Analysis

open access: yes, 2017
Tez (Yüksek Lisans) -- İstanbul Teknik Üniversitesi, Enerji Enstitüsü, 2008Thesis (M.Sc.) -- İstanbul Technical University, Energy Institute, 2008Su ve enerji kaynakların yönetimi ve verimli şekilde kullanılması günümüzün önemli sorunlarından bir ...
Akdağ, Seyit Ahmet
core  

A Class of Fractional Viscoelastic Kirchhoff Equations Involving Two Nonlinear Source Terms of Different Signs

open access: yesAxioms
A class of fractional viscoelastic Kirchhoff equations involving two nonlinear source terms of different signs are studied. Under suitable assumptions on the exponents of nonlinear source terms and the memory kernel, the existence of global solutions in ...
Li Zhang, Yang Liu
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Inverse Dynamics based Energy Assessment and Simulation : IDEAS

open access: yes, 2012
The Standard Assessment Procedure (SAP) is the UK Government’s approved methodology for assessing the energy ratings of dwellings. SAP is a calculation method based upon empirical relations from measured data.
Murphy, Gavin Bruce, Counsell, John
core  

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