Results 51 to 60 of about 1,448,611 (291)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Distributed ABS-Slot Access in Dense Heterogeneous Networks: A Potential Game Approach With Generalized Interference Model

IEEE Access, 2017
This paper investigates the problem of almost blank subframe (ABS)-slot access in the heterogeneous networks to optimize network performance under the ABS scheme.
Kailing Yao, Qihui Wu, Yuhua Xu, Jianjun Jing   +3 more
doaj   +1 more source

Consistency and potentials in cooperative TU-games: Sobolev's reduced game revived [PDF]

, 2000
It was a quarter of a century ago that Sobolev proved the reduced game (otherwise called consistency) property for the much-discussed Shapley value of cooperative TU-games. The purpose of this paper is to extend Sobolev's result in two ways.
Driessen, T.S.H.
core   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Interference Mitigation for Coexisting Wireless Body Area Networks: Distributed Learning Solutions

IEEE Access, 2020
When multiple wireless body area networks (WBANs) exist in close proximity to each other, the inter-user interference considerably degrades the signal to interference plus noise ratio of the packets arriving at each WBAN coordinator.
Emy Mariam George, Lillykutty Jacob
doaj   +1 more source

A Characterization of Ordinal Potential Games [PDF]

Games and Economic Behavior, 1997
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Voorneveld, M., Norde, H.W.
openaire   +4 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Mean-Potential Law in Evolutionary Games [PDF]

Physical Review Letters, 2018
The Letter presents a novel way to connect random walks, stochastic differential equations, and evolutionary game theory. We introduce a new concept of potential function for discrete-space stochastic systems. It is based on a correspondence between one-dimensional stochastic differential equations and random walks, which may be exact not only in the ...
Nałęcz-Jawecki, Paweł, Miękisz, Jacek   +1 more
openaire   +3 more sources

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

An Overhead-Optimizing Task Scheduling Strategy for Ad-hoc Based Mobile Edge Computing

IEEE Access, 2017
In this paper, an overhead-optimizing multi-device task scheduling strategy for ad-hoc-based mobile edge computing system is proposed. This task scheduling strategy takes the opportunity consumption, time delay, energy consumption, and monetary cost into
Li Tianze, Wu Muqing, Zhao Min, Liao Wenxing   +3 more
doaj   +1 more source